• Patients must have histologically confirmed adenocarcinoma arising from the large intestine that has metastasized to the liver. Liver metastases may be synchronous or metachronous.
• The liver metastases must be considered surgically resectable prior to the initiation of study drugs.
• Prior chemotherapy or chemoradiotherapy for colorectal cancer is allowed provided that toxicities from prior therapy have resolved to Grade 1 or less. No prior anti-EGFR or anti-Src therapy is allowed.
• Age >18 years.
• ECOG performance status < 1 (Karnofsky >60%)

• Patients must have organ and marrow function within the parameter defined below:

  • absolute neutrophil count >1.5 x 109/L
  • hemoglobin ≥ 9.0 Gm/dL
  • platelets >100 x 109/L
  • total bilirubin ≤ 1.5 x IULN
  • AST(SGOT)/ALT(SGPT)< 5 x institutional upper limit of normal
  • creatinine <1.5 institutional ULN
• Women must have a negative pregnancy test. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
• Ability to understand and the willingness to sign a written informed consent document.
• Although K-Ras status will be evaluated in the tumor, wild type K-Ras status is not an eligibility criterion.

Exclusion Criteria

• Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
• Patients receiving any other investigational agents.
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to cetuximab or dasatinib.
• Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant women are excluded from this study because of the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with cetuximab or dasatinib, breastfeeding should be discontinued if the mother is treated with cetuximab or dasatinib.
• Patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy. Therefore, HIV-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with cetuximab or dasatinib. Appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated.
• Patients on potent CYP3A4 inducers and inhibitors.

Inclusion of Women and Minorities Both men and women and members of all races and ethnic groups are eligible for this trial.