Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease
Objective: To investigate the potential role of endothelial dysfunction as a pathogenic mechanism of cardiovascular events in COPD. Hypothesis: endothelial function is abnormal in patients with COPD, particularly during exacerbations of the disease. Design: prospective and controlled study performed in an university hospital. Population: we compare 4 groups of subjects, 44 patients with stable COPD, 35 patients with acute exacerbation of COPD, 10 smokers or former smokers with normal lung function and 10 never smokers matched by physical activity and BMI. Study variables: a) clinical variables: clinical information, physical examination, pulmonary function tests, ECG and sputum culture; b) Biological variables: number of Circulating Endothelial Progenitor Cells, vascular growth factors (vascular endothelial growht factor and erythropoietin), systemic inflammation (C-reactive protein, white blood cells), peripheral venous blood test (including hemogram, biochemical analysis with glycemia, cholesterol, LDLcol, HDLcol); and c) systemic vascular reactivity assessment.
Chronic Obstructive Pulmonary Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease|
Plasma and serum.
|Study Start Date:||March 2005|
|Study Completion Date:||October 2007|
|Primary Completion Date:||October 2007 (Final data collection date for primary outcome measure)|
Patients with a COPD exacerbation
Patients with stable COPD
Smokers or former smokers
|Hospital Universitari Son Dureta|
|Palma Mallorca, Illes Balears, Spain, 07014|
|Principal Investigator:||Ernest Sala, MD||Servei de Pneumologia, Hospital Universitari Son Dureta|