Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease
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Purpose
Objective: To investigate the potential role of endothelial dysfunction as a pathogenic mechanism of cardiovascular events in COPD. Hypothesis: endothelial function is abnormal in patients with COPD, particularly during exacerbations of the disease. Design: prospective and controlled study performed in an university hospital. Population: we compare 4 groups of subjects, 44 patients with stable COPD, 35 patients with acute exacerbation of COPD, 10 smokers or former smokers with normal lung function and 10 never smokers matched by physical activity and BMI. Study variables: a) clinical variables: clinical information, physical examination, pulmonary function tests, ECG and sputum culture; b) Biological variables: number of Circulating Endothelial Progenitor Cells, vascular growth factors (vascular endothelial growht factor and erythropoietin), systemic inflammation (C-reactive protein, white blood cells), peripheral venous blood test (including hemogram, biochemical analysis with glycemia, cholesterol, LDLcol, HDLcol); and c) systemic vascular reactivity assessment.
| Condition |
|---|
|
Chronic Obstructive Pulmonary Disease Endothelial Dysfunction |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease |
Plasma and serum.
| Enrollment: | 99 |
| Study Start Date: | March 2005 |
| Study Completion Date: | October 2007 |
| Primary Completion Date: | October 2007 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
1
Patients with a COPD exacerbation
|
|
2
Patients with stable COPD
|
|
3
Smokers or former smokers
|
|
4
Never smokers
|
Eligibility| Ages Eligible for Study: | 45 Years and older |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Patients with an exacerbation of COPD admitted to our hospital, stable COPD recruited in an ambulatory basis, smokers or former smokers and never smokers recruited in our laboratory.
Inclusion Criteria:
- Patients with moderate to very severe COPD admitted in the hospital because of an exacerbation, and,
- Patients with moderate to very severe COPD in stable condition.
Exclusion Criteria:
- Patients with an exacerbation of COPD who needed invasive or non invasive mechanical ventilation
- Patients with other chronic inflammatory diseases.
- Patients with other acute or active chronic systemic disease such as heart failure, renal insufficiency, etc.
Contacts and Locations| Spain | |
| Hospital Universitari Son Dureta | |
| Palma Mallorca, Illes Balears, Spain, 07014 | |
| Principal Investigator: | Ernest Sala, MD | Servei de Pneumologia, Hospital Universitari Son Dureta |
More Information
No publications provided
| Responsible Party: | Dr. Ernest Sala, Servei de Pneumologia, Hospital Universitari Son Dureta |
| ClinicalTrials.gov Identifier: | NCT00831220 History of Changes |
| Other Study ID Numbers: | PI04/1946 |
| Study First Received: | January 27, 2009 |
| Last Updated: | January 27, 2009 |
| Health Authority: | Spain: Ethics Committee |
Keywords provided by Hospital Universitari Son Dureta:
|
COPD exacerbations EPCs |
Erythropoietin C-RP COPD and endothelial dysfunction |
Additional relevant MeSH terms:
|
Lung Diseases Respiration Disorders Pulmonary Disease, Chronic Obstructive Lung Diseases, Obstructive Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on June 18, 2013