Improving Human Ovarian Transplantation
This study is ongoing, but not recruiting participants.
Sponsor:
Hadassah Medical Organization
Collaborator:
Israel Science Foundation
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00827476
First received: January 21, 2009
Last updated: NA
Last verified: January 2009
History: No changes posted
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Purpose
we will perform xenotransplantation and in vitro culture of ovarian tissue from patients undergoing ovarian cortex cryopreservation.
| Condition | Intervention | Phase |
|---|---|---|
|
Fertility Preservation |
Procedure: ovarian transplantation |
Phase 0 |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Phase 1 Study to Improve Results of Human Ovarian Transplantation |
Resource links provided by NLM:
Further study details as provided by Hadassah Medical Organization:
Primary Outcome Measures:
- improving folliculogenesis and oocuyte maturation after ovarian transplantation [ Time Frame: 2 years ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 100 |
| Study Start Date: | January 2009 |
| Estimated Study Completion Date: | January 2015 |
| Estimated Primary Completion Date: | January 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: ovarian transplantation
tissue will be used for xenotransplantation or in vitro culture
|
Procedure: ovarian transplantation
ovarian xenotransplantation or in vitro culture
|
Detailed Description:
Ovarian tissue is removed by laparoscopy and only in patients facing premature ovarian failure due to chemotherapy.Tissue for research will consist either of a small portion (<10%) of the cortex for preservation for young women. another source of ovarian tissue for research will be obtained following consent from family of patients who have died of the disease and have previously frozen ovarian tissue.
Eligibility| Ages Eligible for Study: | 5 Years to 40 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- tissue previously obtained
Exclusion Criteria:
- no tissue available or no consent
Contacts and Locations
No Contacts or Locations Provided
More Information
No publications provided
| Responsible Party: | Ariel Revel, Hadassah Medical Organization |
| ClinicalTrials.gov Identifier: | NCT00827476 History of Changes |
| Other Study ID Numbers: | 0530-08-HMO- CTIL |
| Study First Received: | January 21, 2009 |
| Last Updated: | January 21, 2009 |
| Health Authority: | Israel: Ministry of Health |
Keywords provided by Hadassah Medical Organization:
|
ovary human transplantaion ovarian failure |
Additional relevant MeSH terms:
|
Infertility Genital Diseases, Male Genital Diseases, Female |
ClinicalTrials.gov processed this record on May 21, 2013