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Fluorine-18-α-Methyltyrosine Positron Emission Tomography (18F-FMT PET) for Therapy Response in Lung Cancer

This study has been completed.
Sponsor:
Collaborator:
J~pharma
Information provided by:
Gunma University
ClinicalTrials.gov Identifier:
NCT00826033
First received: January 20, 2009
Last updated: NA
Last verified: January 2009
History: No changes posted
  Purpose

L-[3-18F]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for positron emission tomography (PET). The investigators evaluated the value of 18F-FMT PET for the assessment of therapy response in patients with lung cancer as compared with that of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET.

The patients with lung cancer underwent PET studies with 18F-FDG and 18F-FMT before and after radio-/chemotherapy. The investigators used the ratio of the SUVmax of the mediastinal (N2) lymph node to the SUVmax of the primary tumor (N/P ratio ). All patients were divided into two groups of N/P ratio<1 and N/P ratio≥1, and the survival time was estimated by Kaplan-Meier method.


Condition
Non-Small Cell Lung Cancer

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Fluorine-18-α-Methyltyrosine Positron Emission Tomography to Measure Therapy

Resource links provided by NLM:

MedlinePlus related topics: Cancer Lung Cancer
U.S. FDA Resources

Further study details as provided by Gunma University:

Groups/Cohorts
Therapy monitoring

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

This study was conducted at the Gunma University Hospital.

Criteria

Inclusion Criteria:

  • primary lung cancer All patients received first-line chemotherapy

Exclusion Criteria:

  • Patients with diabetus mellitus
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00826033

Locations
Japan
Gunma University Graduate School of Medicine
Gunma, Japan, 371-8511
Sponsors and Collaborators
Gunma University
J~pharma
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00826033     History of Changes
Other Study ID Numbers: Mol Imaing 1
Study First Received: January 20, 2009
Last Updated: January 20, 2009
Health Authority: Japan: Ministry of Health, Labor and Welfare

Keywords provided by Gunma University:
Fluorine-18-α-methyltyrosine
Positron emission tomography
Lung cancer
chemotherapy
monitoring

Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Carcinoma, Bronchogenic
Bronchial Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
 Lung Diseases
Respiratory Tract Diseases
Fluorides
Cariostatic Agents
Protective Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on May 23, 2013