Phenytoin and Multidose Activated Charcoal
Phenytoin is a medicine used to treat seizures. If too much is taken, patients have ill effects including sleepiness, unsteady gait, and eye problems. The amount of drug in their system can be measured in their blood. Charcoal is a medicine that can absorb phenytoin. We want to see if giving multiple doses of charcoal will quicken the removal of phenytoin from the blood. This is theorized to occur as charcoal absorbs phenytoin from across the intestines and then is secreted in the stool. Patients will be selected to receive either charcoal in multiple doses or no charcoal and their serum levels will be drawn repeatedly to follow their level. The different groups will then be compared to see if multidose charcoal does indeed shorten the half-life of phenytoin in the blood.
|Study Design:||Allocation: Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Prospective Randomized Study of Multidose Activated Charcoal in Supratherapeutic Phenytoin Serum Levels|
- Serum Phenytoin 1/2 life. [ Time Frame: Every hours initially then once a day ] [ Designated as safety issue: No ]
|Study Start Date:||August 2008|
|Study Completion Date:||January 2012|
|Primary Completion Date:||July 2010 (Final data collection date for primary outcome measure)|
Patients will receive multiple doses of activated charcoal
Drug: Activated Charcoal
50 grams by mouth every 4 hours until serum phenytoin level is less than 25.
No Intervention: 2
Will not receive activated charcoal. Serum levels will be followed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00823264
|United States, Georgia|
|Grady Memorial Hospital|
|Atlanta, Georgia, United States, 30303|
|Principal Investigator:||Carl Skinner, MD||Emory University|