Trial record 13 of 3045 for:
"Depressive Disorder" [DISEASE]
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
This study has been completed.
Sponsor:
University of Aarhus
Collaborators:
The Ministry of Science, Technology and Innovation, Denmark
Vejle Hospital
Danish National Research Foundation
Aarhus University Hospital
Augustinusfonden,
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00818506
First received: January 6, 2009
Last updated: November 20, 2012
Last verified: November 2012
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Purpose
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.
| Condition |
|---|
|
Depression Major Depressive Disorder Cardiovascular Disease Coronary Artery Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder |
Resource links provided by NLM:
Further study details as provided by University of Aarhus:
Biospecimen Retention: Samples With DNA
Whole Blood
| Enrollment: | 55 |
| Study Start Date: | March 2009 |
| Study Completion Date: | June 2012 |
| Groups/Cohorts |
|---|
|
Late onset MDD
Patients with major depressive disorder between 50 and 70 years of age that did not suffer from depression before the age of 50.
|
|
Controls
Healthy controls (matched for age, sex, and tobacco use status)
|
Eligibility| Ages Eligible for Study: | 50 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Study Population
Psychiatric treatment facilities (e.g. psychiatric hospital, private psychiatrist).
Criteria
INCLUSION CRITERIA:
- Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.
- Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).
- Age 50-70 years.
- Written informed consent.
- Caucasian.
EXCLUSION CRITERIA:
- Known, or anamnestic/objective signs of, organic brain disease.
- Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).
- Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.
- Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).
- Subject to force of law according to the danish law on psychiatry.
- Present risk of suicide.
- Previous cranial trauma resulting in unconsciousness for more than 2 minutes.
- Medical history of renal failure.
- Other conditions which contraindicate specific procedures in the project.
- Other conditions deemed to prevent the subject from completing the examination program.
- Does not want to participate.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00818506
Locations
| Denmark | |
| Center of Psychiatric Research, Aarhus University Hospital | |
| Aarhus, Denmark, 8200 | |
Sponsors and Collaborators
University of Aarhus
The Ministry of Science, Technology and Innovation, Denmark
Vejle Hospital
Danish National Research Foundation
Aarhus University Hospital
Augustinusfonden,
Investigators
| Study Director: | Poul Videbech, Professor, M.D., Dr.Med. | Center of Psychiatric Research, Aarhus University Hospital |
More Information
No publications provided
| Responsible Party: | University of Aarhus |
| ClinicalTrials.gov Identifier: | NCT00818506 History of Changes |
| Other Study ID Numbers: | CPF-TAD-1 |
| Study First Received: | January 6, 2009 |
| Last Updated: | November 20, 2012 |
| Health Authority: | Denmark: Ethics Committee |
Keywords provided by University of Aarhus:
|
Depression Major depressive disorder Coronary artery disease |
White Matter Hyperintensities White Matter Lesions Coronary artery calcification |
Additional relevant MeSH terms:
|
Depression Depressive Disorder Depressive Disorder, Major Cardiovascular Diseases Coronary Artery Disease Myocardial Ischemia Coronary Disease |
Heart Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Behavioral Symptoms Mood Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 23, 2013