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Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

This study has been completed.
Sponsor:
Collaborators:
The Ministry of Science, Technology and Innovation, Denmark
Vejle Hospital
Danish National Research Foundation
Aarhus University Hospital
Augustinusfonden,
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00818506
First received: January 6, 2009
Last updated: November 20, 2012
Last verified: November 2012
  Purpose

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.


Condition
Depression
Major Depressive Disorder
Cardiovascular Disease
Coronary Artery Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder

Further study details as provided by University of Aarhus:

Biospecimen Retention:   Samples With DNA

Whole Blood


Enrollment: 55
Study Start Date: March 2009
Study Completion Date: June 2012
Groups/Cohorts
Late onset MDD
Patients with major depressive disorder between 50 and 70 years of age that did not suffer from depression before the age of 50.
Controls
Healthy controls (matched for age, sex, and tobacco use status)

  Eligibility

Ages Eligible for Study:   50 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Psychiatric treatment facilities (e.g. psychiatric hospital, private psychiatrist).

Criteria

INCLUSION CRITERIA:

  • Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.
  • Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).
  • Age 50-70 years.
  • Written informed consent.
  • Caucasian.

EXCLUSION CRITERIA:

  • Known, or anamnestic/objective signs of, organic brain disease.
  • Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).
  • Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.
  • Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).
  • Subject to force of law according to the danish law on psychiatry.
  • Present risk of suicide.
  • Previous cranial trauma resulting in unconsciousness for more than 2 minutes.
  • Medical history of renal failure.
  • Other conditions which contraindicate specific procedures in the project.
  • Other conditions deemed to prevent the subject from completing the examination program.
  • Does not want to participate.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00818506

Locations
Denmark
Center of Psychiatric Research, Aarhus University Hospital
Aarhus, Denmark, 8200
Sponsors and Collaborators
University of Aarhus
The Ministry of Science, Technology and Innovation, Denmark
Vejle Hospital
Danish National Research Foundation
Aarhus University Hospital
Augustinusfonden,
Investigators
Study Director: Poul Videbech, Professor, M.D., Dr.Med. Center of Psychiatric Research, Aarhus University Hospital
  More Information

No publications provided

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00818506     History of Changes
Other Study ID Numbers: CPF-TAD-1
Study First Received: January 6, 2009
Last Updated: November 20, 2012
Health Authority: Denmark: Ethics Committee

Keywords provided by University of Aarhus:
Depression
Major depressive disorder
Coronary artery disease
White Matter Hyperintensities
White Matter Lesions
Coronary artery calcification

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Depression
Depressive Disorder
Depressive Disorder, Major
Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Arteriosclerosis
Behavioral Symptoms
Heart Diseases
Mental Disorders
Mood Disorders
Pathologic Processes
Vascular Diseases

ClinicalTrials.gov processed this record on November 24, 2014