Text Size

Impact of a Sleep Debt in Middle-Aged and Older Adults (PPG)

This study has been completed.
Sponsor:
Information provided by:
University of Chicago
ClinicalTrials.gov Identifier:
NCT00817700
First received: January 5, 2009
Last updated: July 21, 2009
Last verified: July 2009
History of Changes
  Purpose

This project has 6 aims.

  1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
  2. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
  3. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
  4. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
  5. To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
  6. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Condition Intervention
Healthy Volunteers
 Other: Sleep restriction and recovery

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery. [ Time Frame: Completion of 23 day study ] [ Designated as safety issue: No ]

Estimated Enrollment: 72
Study Start Date: April 2005
Study Completion Date: May 2008
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: Sleep restriction and recovery
    Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.
  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • normal weight
  • healthy
  • age 18-75 old

Exclusion Criteria:

  • sleep disorder
  • irregular life habits (shift workers, travelers)
  • smokers
  • on medication
  • consumption of > 2 alcohol or caffeinated beverages/day
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00817700

Locations
United States, Illinois
The University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: Eve Van Cauter, PhD University of Chicago
  More Information

No publications provided

Responsible Party: Eve Van Cauter, PhD, Professor, The University of Chicago
ClinicalTrials.gov Identifier: NCT00817700     History of Changes
Other Study ID Numbers: #13159A, 5-PO1 AG11412
Study First Received: January 5, 2009
Last Updated: July 21, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by University of Chicago:
Sleep
young adults
middle-age adults
older adults

ClinicalTrials.gov processed this record on May 23, 2013