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Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy (CRIC)

This study has been completed.
University of Illinois at Chicago
Case Western Reserve University
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: January 5, 2009
Last updated: September 4, 2013
Last verified: September 2013

To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by C-reactive protein in the blood. The study will explore the role of decreased sleep time or decreased sleep quality as a non-traditional risk factor for the progression of CKD and for the development of cardiovascular disease in CKD.

Chronic Kidney Disease
Sleep Loss

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Sleep Disturbances as a Non-traditional Risk Factor in CKD-Wrist Actigraphy

Resource links provided by NLM:

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • CKD progression as measured by changes in GFR and cardiovascular risk as measured by CRP over a 5 year period [ Time Frame: 5 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • insulin resistance [ Time Frame: 5 years ] [ Designated as safety issue: No ]

Enrollment: 353
Study Start Date: November 2007
Study Completion Date: October 2010
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
CKD subjects
Healthy Controls


Ages Eligible for Study:   21 Years to 74 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

CKD subjects; healthy volunteers


Inclusion Criteria:

  • Mild to Moderate CKD
  • Healthy controls age and gender matched to CKD subjects
  • Regular bedtimes of at least 6h/night, sedentary lifestyle

Exclusion Criteria:

  • Diabetes
  • Current or previous dialysis for more than 1 month
  • Uncontrolled hypertension
  • Heart failure
  • Liver disease
  • HIV
  • Hemoglobin < 10.5 g/dl
  • Treatment with EProcrit, Epogen, or Aranesp
  • Bone or organ transplant,
  • Use of immunosuppressive drugs within past 6 months
  • Current oral contraceptive use
  • Current pregnancy
  • Chemotherapy for malignancy within past 2 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT00817674

United States, Illinois
The University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
University of Illinois at Chicago
Case Western Reserve University
Principal Investigator: Eve Van Cauter, PhD University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago Identifier: NCT00817674     History of Changes
Other Study ID Numbers: #14081A, 5RO1DK71696
Study First Received: January 5, 2009
Last Updated: September 4, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Chicago:
Kidney Disease
poor sleep
CKD progression

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Sleep Disorders
Mental Disorders
Nervous System Diseases
Neurologic Manifestations
Renal Insufficiency
Signs and Symptoms
Urologic Diseases processed this record on November 25, 2014