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Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat (FEIGH)

This study has been completed.
Sponsor:
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00817440
First received: January 5, 2009
Last updated: January 10, 2011
Last verified: January 2011
History of Changes
  Purpose

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.

In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.


Condition Intervention
Healthy
 Other: Exercise
Other: Fasting

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Growth hormone and insulin signal pathways [ Time Frame: 30 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • aminoacid and glucose turnover [ Time Frame: 4 hours ] [ Designated as safety issue: No ]

Enrollment: 8
Study Start Date: December 2008
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Control
control: muscle and fat biopsies and basal aminoacid and glucose turnover
Experimental: Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
 Other: Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
Experimental: Fasting
3 days of fasting and then the same as arm 1
 Other: Fasting
3 days of fasting and then the same as arm 1

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion Criteria:

  • any kind of disease
  • any use of medicine
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00817440

Locations
Denmark
Aarhus sygehus
Aarhus, Jylland, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

No publications provided

Responsible Party: Mikkel Vendelbo MD, endokrinologiskforskningslaboratorium M, Aarhus sygehus
ClinicalTrials.gov Identifier: NCT00817440     History of Changes
Other Study ID Numbers: 16.12.2008
Study First Received: January 5, 2009
Last Updated: January 10, 2011
Health Authority: Denmark: Ethics Committee

Keywords provided by University of Aarhus:
growth hormone insulin signaltransduction signalpathways
growth hormone and insulin signalpathways

Additional relevant MeSH terms:
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on June 17, 2013