Drug /Cue Interactions In Alcohol-Tobacco Comorbidity
The purpose of this study is to determine how people react to different combinations of alcohol and nicotine.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
|Official Title:||Drug /Cue Interactions In Alcohol-Tobacco Comorbidity|
- Psychophysiological Reactivity Assessment [ Time Frame: approximately 5 weeks per participant ] [ Designated as safety issue: No ]To assess cravings and psychophysiological reactivity elicited by alcohol, smoking, and neutral cues following acute intake of alcohol and nicotine among individuals across a broad range of alcohol and cigarette use patterns (Study 1).
- Alcohol Self-administration Assessment [ Time Frame: approximately 5 weeks per participant. ] [ Designated as safety issue: No ]To assess alcohol self-administration upon exposure to alcohol or smoking-related cues following acute intake of alcohol, nicotine, or both drugs among individuals across a broad range of alcohol and cigarette use patterns (Study 2).
|Study Start Date:||May 2006|
|Estimated Study Completion Date:||March 2015|
|Primary Completion Date:||March 2014 (Final data collection date for primary outcome measure)|
|Experimental: Drug/Cue Interactions||
Behavioral: Tobacco Research and Intervention Program
Five research sessions. Session 1: Questionnaires, interviews, computer task, medical evaluation. Sessions 2 - 5: Lab Sessions involving tobacco and alcohol with brief summary at the end of the last session.
Other Name: TRIP
The present project will improve and expand upon previously published work in several ways. First, Study 1 will assess reactivity to alcohol and smoking cues in the same session. Second, both studies will include within-subjects design factors to manipulate alcohol and nicotine intake, as well as cue types. Third, craving indices will represent three important response domains: subjective, physiological, and behavioral (e.g., Niaura et al., 1991). Fourth, each study will evaluate a range of drinkers and smokers, which will provide maximal information concerning influences on alcohol and smoking cue reactivity across various subject populations. The proposed studies are not only important from a theory development perspective, but they will provide an excellent foundation for future laboratory-based and clinical research.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00816231
|United States, Florida|
|H. Lee Moffitt Cancer Center & Research Institute|
|Tampa, Florida, United States, 33612|
|Principal Investigator:||David Drobes, Ph.D.||H. Lee Moffitt Cancer Center and Research Institute|