Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level

This study has been withdrawn prior to enrollment.
(because of unexpected administrative barrier, it was very difficult to enroll case.)
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00815230
First received: December 25, 2008
Last updated: May 17, 2009
Last verified: December 2008
  Purpose

The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we can reach, there is no report concerning the relation between X-ray computed tomography examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if the cardiac computed tomography angiography (cardiac CTA) may induce a higher level of ROS in the peripheral blood.

Study subjects will be OPD patients who are arranged for cardiac CTA examination because of suspect coronary artery disease (CAD). In total, twenty cases will be enrolled for the study. The formal consent will be delivered and explained to the patients and families after the arrangement of cardiac CTA. It then will be retrieved just before the performance of cardiac CTA.

For each enrolled case, peripheral blood will be sampled three times (once before and twice after the performance of cardiac CTA). Totally 60 blood samples will be collected from 20 study subjects within 3 months (January 1 ~ March 31, 2009). ROS level in the collected blood samples will be then measured, compared, and analyzed.


Condition
Radiation Injury

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   None Retained

only peripheral blood will be collected for measurement of reactive oxygen species.


Estimated Enrollment: 20
Study Start Date: January 2009
Estimated Study Completion Date: March 2009
  Eligibility

Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Study subjects will be OPD patients who are arranged for cardiac CTA examination because of suspect coronary artery disease.

Criteria

Inclusion Criteria:

  • subjects who are arranged for cardiac CTA examination because of suspect coronary artery disease.

Exclusion Criteria:

  • none
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00815230

Locations
Taiwan
NTUH
Taipei, Taiwan, 10002
Sponsors and Collaborators
National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: Zei-Shung Huang, associate professor, Department of Internal Medicine, NTUH, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00815230     History of Changes
Other Study ID Numbers: 200812057R
Study First Received: December 25, 2008
Last Updated: May 17, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
radiation injury
computed tomography
reactive oxygen species
free radicals

Additional relevant MeSH terms:
Radiation Injuries
Wounds and Injuries

ClinicalTrials.gov processed this record on July 22, 2014