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Effect of β-alanine Supplementation on Muscle Carnosine (LitmusMagnet)

This study has been completed.
Sponsor:
Collaborators:
University of Bern
University Hospital Inselspital, Berne
Information provided by (Responsible Party):
Nestlé
ClinicalTrials.gov Identifier:
NCT00813553
First received: December 22, 2008
Last updated: April 24, 2012
Last verified: April 2012
History of Changes
  Purpose

Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.


Condition Intervention
Healthy
 Dietary Supplement: placebo
Dietary Supplement: beta-alanine

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Official Title: Effect of Two 8-week β-alanine Supplementation Protocols on Muscle Carnosine

Resource links provided by NLM:

Drug Information available for: Alanine
U.S. FDA Resources

Further study details as provided by Nestlé:

Primary Outcome Measures:
  • muscle carnosine concentration [ Time Frame: 0 to 8 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: December 2008
Study Completion Date: October 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: beta-alanine 0 Dietary Supplement: placebo
daily
Experimental: beta-alanine 1 Dietary Supplement: beta-alanine
daily
Experimental: beta-alanine 2 Dietary Supplement: beta-alanine
daily

Detailed Description:

Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Stable health as evaluated by medical evaluation
  • Body mass index higher than 18 kg/m2
  • Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion Criteria:

  • intolerance to β-alanine,
  • allergy to soy, fish and crustacean
  • participation in another intervention study
  • consumer of dietary supplement susceptible to contain beta-alanine
  • determined to have very high baseline muscle carnosine concentration
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00813553

Locations
Switzerland
University and Inselspital
Bern, Switzerland, 3010
Sponsors and Collaborators
Nestlé
University of Bern
University Hospital Inselspital, Berne
  More Information

No publications provided

Responsible Party: Nestlé
ClinicalTrials.gov Identifier: NCT00813553     History of Changes
Other Study ID Numbers: 08.13.PER
Study First Received: December 22, 2008
Last Updated: April 24, 2012
Health Authority: Switzerland: Ethikkommission

Keywords provided by Nestlé:
physical fitness
exercise
amino acid

ClinicalTrials.gov processed this record on May 23, 2013