Neural Correlates of Psychodynamic Psychotherapy for Depression
The purpose of this study is to see whether we can predict which patients with depression will get better when we treat them with psychodynamic psychotherapy. We will use neuroimaging (a method of looking at brain activity) in this study. We want to see whether there are changes in the brains of patients receiving this type of therapy. We hypothesize that these changes may predict how well certain parts of the psychotherapy treatment process works.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Neural Correlates of Psychodynamic Psychotherapy for Depression|
- Correlation between changes in HAMD-17 and changes in QEEG measurements (theta cordance) from treatment initiation to two weeks after starting treatment [ Time Frame: Weeks 0 through 16 ] [ Designated as safety issue: No ]
- PET: Treatment-related change in FDG metabolism within regions-of-interest identified at baseline as related to depression severity. [ Time Frame: Week 0, Week 16 ] [ Designated as safety issue: No ]
|Study Start Date:||August 2008|
|Study Completion Date:||February 2013|
|Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
|Experimental: Psychodynamic psychotherapy||
Behavioral: Psychodynamic Psychotherapy
Screened and eligible patients will receive 16 individual sessions of psychodynamic psychotherapy, each lasting 45-50 minutes.
In this study, we will treat patients with brief psychodynamic psychotherapy. Psychodynamic psychotherapy is a type of treatment that may be as helpful as medications in treating depression. It focuses on thoughts, feelings, and behaviors as well as both current and past relationships. Psychotherapy explores better ways of coping with feelings, expressing needs, and interacting with others in order to cope with depression and other life problems. Subjects will go to 16 weekly, 45-minute, individual sessions of psychodynamic psychotherapy over the course of the study. At five times throughout the study, subjects will come in for extra visits, which last approximately 1.5 hours and which include: speaking with a study doctor about depressive symptoms, filling out extra questionnaires, and performing positron emission tomography (PET)and a Quantitative Electroencephalogram (QEEG). The QEEG is a machine that measures the electrical activity of the brain. This task will take approximately 15 minutes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00812227
|United States, Massachusetts|
|Depression Clinical and Research Program|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Joshua Roffman, MD||Massachusetts General Hospital Department of Psychiatry|
|Principal Investigator:||Janet Witte, MD, MPH||Massachusetts General Hospital Department of Psychiatry|