Genomic Approaches to Common Chronic Disease - Ancillary to ARIC

This study has been completed.
Sponsor:
Collaborators:
University of Texas
Cornell University
Baylor College of Medicine
Washington University School of Medicine
Information provided by:
University of Michigan
ClinicalTrials.gov Identifier:
NCT00808353
First received: December 12, 2008
Last updated: NA
Last verified: December 2008
History: No changes posted
  Purpose

The ARIC study is a prospective epidemiologic study conducted in four U.S. communities and designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date.


Condition
Cardiovascular Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Genomic Approaches to Common Chronic Disease

Resource links provided by NLM:


Further study details as provided by University of Michigan:

Primary Outcome Measures:
  • Cardiovascular disease and its risk factors [ Time Frame: One year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Additional common chronic disease risk factors [ Time Frame: One year ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Blood and urine


Enrollment: 15792
Study Start Date: July 1985
Detailed Description:

The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date.

ARIC includes two parts: the Cohort Component and the Community Surveillance Component. The Cohort Component began in 1987, and each ARIC field center randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive examination, including medical, social, and demographic data. These participants were reexamined every three years with the first screen (baseline) occurring in 1987-89, the second in 1990-92, the third in 1993-95, and the fourth and last exam was in 1996-98. Follow-up occurs yearly by telephone to maintain contact with participants and to assess health status of the cohort.

In the Community Surveillance Component, currently ongoing, these four communities are investigated to determine the community-wide occurrence of hospitalized myocardial infarction and coronary heart disease deaths in men and women aged 35-84 years. Hospitalized stroke is investigated in cohort participants only. The study conducts community surveillance of inpatient heart failure (ages 55 years and older) and cohort surveillance outpatient heart failure events beginning in 2005.

  Eligibility

Ages Eligible for Study:   45 Years to 64 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

The ARIC study is a prospective epidemiologic study conducted in four U.S. communities The ARIC study began in 1987, with each field center randomly selecting and recruiting a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. These participants were reexamined every three years with the first screen (baseline) occurring in 1987-89, the second in 1990-92, the third in 1993-95, and the fourth and last exam was in 1996-98. Follow-up occurs yearly by telephone to maintain contact with participants and to assess health status of the cohort.

Criteria

Inclusion Criteria:

  • The ARIC study began in 1987, and each ARIC field center randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community

Exclusion Criteria:

  • Those not meeting the inclusion criteria
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00808353

Sponsors and Collaborators
University of Michigan
University of Texas
Cornell University
Baylor College of Medicine
Washington University School of Medicine
Investigators
Principal Investigator: Eric Boerwinkle, PhD Univeristy of Texas Houston Health Science Center School of Public Health
  More Information

No publications provided

Responsible Party: Charles F. Sing/Professor, University of Michigan
ClinicalTrials.gov Identifier: NCT00808353     History of Changes
Other Study ID Numbers: CFDA No: 93.859, 5 P50 GM065509
Study First Received: December 12, 2008
Last Updated: December 12, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by University of Michigan:
CVD

Additional relevant MeSH terms:
Cardiovascular Diseases
Chronic Disease
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on April 17, 2014