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Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study (VIMPAC)

This study has been completed.
Sponsor:
Collaborator:
Rajavithi Biomolecular Research Center
Information provided by:
Rajavithi Hospital
ClinicalTrials.gov Identifier:
NCT00807378
First received: December 9, 2008
Last updated: May 19, 2010
Last verified: May 2010
History of Changes
  Purpose

This study of neurotropic viral infection and Tuberculous CNS infection is the comprehensive investigation of CSF PCR arrays (Hybrydiaztion technique,Sybergreen and Taqman real time PCR arrays of CSF ) in suspected cases of viral CNS infection, Tuberculous CNS infection in both AIDS and non AIDS patients.

Patients with clinical viral encephalitis and all meningoencephalitis including all patients with HIV/AIDS CSF and non AIDS will be banked and test for RNA and DNA viral sequence by Real time PCR arrays and IS6110 gene of Mycobacterium tuberculosis. Clinical data and final diagnosis will be used to analyze the result of this PCR arrays technique compared to clinical gold standard criteria.


Condition Intervention
CNS Viral Infection
 Other: LUMBAR PUNCTURE

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cerebrospinal Fluid Polymerase Chain Reaction Arrays for Central Nervous System Neurotropic Viral Infection and Mycobacterium Infection Study

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Rajavithi Hospital:

Biospecimen Retention:   Samples With DNA

CSF DNA/RNA virus


Estimated Enrollment: 200
Study Start Date: July 2008
Study Completion Date: March 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
AIDS PATIENTS
 Other: LUMBAR PUNCTURE
LUMBAR PUNCTURE FFOR CSF COLLECTION
2
NON-AIDS PATIENTS
 Other: LUMBAR PUNCTURE
LUMBAR PUNCTURE FFOR CSF COLLECTION

  Eligibility

Ages Eligible for Study:   15 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

CNS VIRAL INFECTION AIDS/NON-AIDS

Criteria

Inclusion Criteria:

  1. AGE MORE THAN 15 YRS
  2. ABLE TO INFORM CONSENT BY THEMSELF OR THEIR PARENT
  3. SUSPECTED CNS VIRAL INFECTION

Exclusion Criteria:

  1. UNABLE/CONTRAINDICATED FOR LUMBAR PUNCTURE OR CSF COLLECTION
  2. WITHDRAW CONSENT
  3. SUSPECTED SEVERE OR VILURENT VIRAL INFECTION SUCH AS H5N1/SARS INFECTION
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Piyathida Harnsomboonrana, Rajavithi Biomolecular Research Center
ClinicalTrials.gov Identifier: NCT00807378     History of Changes
Other Study ID Numbers: RH-CMR-004
Study First Received: December 9, 2008
Last Updated: May 19, 2010
Health Authority: Thailand: Ministry of Public Health

Keywords provided by Rajavithi Hospital:
CNS viral infection
PCR
HYBRIDIZATION

Additional relevant MeSH terms:
Mycobacterium Infections
Virus Diseases
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections

ClinicalTrials.gov processed this record on June 18, 2013