FOLFIRI and Sunitinib in Metastatic Colorectal Cancer

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Central European Society for Anticancer Drug Research
ClinicalTrials.gov Identifier:
NCT00806663
First received: December 10, 2008
Last updated: September 7, 2012
Last verified: September 2012
  Purpose

This is an open label single arm prospective multicenter Phase II study in around 20 patients. The primary objective of this study is to evaluate whether the addition of sunitinib to FOLFIRI results in a significant reduction of tumor vessel permeability (TVP) and blood flow (BF) measured by DCE-MRI and DCE-USI, measured on liver metastases.

Secondary objectives are antitumor response, time to progression (TTP), effect on pharmacokinetics of sunitinib and biomarkers (VEGF und soluble VEGF-receptor) and drug/treatment safety.


Condition Intervention Phase
Metastatic Colorectal Cancer
Liver Metastases
Drug: sunitinib added to FOLFIRI
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Prospective Angiogenic Imaging Study With DCE-MRI and DCE-USI in Patients With Colorectal Cancer and Liver Metastases Receiving Sunitinib in Addition to 5-FU, Folinic Acid and Irinotecan (FOLFIRI) as 1st Line Therapy

Resource links provided by NLM:


Further study details as provided by Central European Society for Anticancer Drug Research:

Primary Outcome Measures:
  • reduction of tumor vessel permeability (TVP) and blood flow (BF) measured by DCE-MRI and DCE-USI, measured on liver metastases. [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Antitumour response [ Time Frame: 9 months ] [ Designated as safety issue: No ]
  • Time to progression (TTP) [ Time Frame: 9 months ] [ Designated as safety issue: No ]
  • pharmacokinetics [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
  • drug treatment safety [ Time Frame: 9 months ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 22
Study Start Date: August 2008
Study Completion Date: September 2011
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: sunitinib added to FOLFIRI
    sunitinib 37 mg once daily (4 weeks on/2 weeks off)
    Other Name: Sutent
  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adult males and females: over 18 years of age.
  • Patients with histologically or cytologically confirmed colorectal cancer who will receive their first palliative treatment.
  • Patients who have at least one measurable hepatic lesion of 2 cm or more according to RECIST criteria.
  • ECOG 0 or 1.
  • Signed written informed consent.
  • White blood cell count (WBC)>= 4x10^9/L with neutrophils >= 1.5 x 10*9/L, platelet count >= 100x10*9/L, hemoglobin >= 5.6 mmol/L (10 g/dL).
  • Total bilirubin =< 2 x upper limit of normal.
  • AST and ALT =< 2.5 x upper limit of normal, or =< 5 x upper limit of normal in case of liver metastases.
  • Serum creatinine =< 1.5 x upper limit of normal or creatinine clearance > 60 ml/min
  • Normal ECG without QT prolongation.

Exclusion Criteria:

  • Resectable liver metastasis.
  • Adjuvant therapy with FOLFOX or 5-FU / Capecitabine =< 6 months prior to treatment on study or any previous palliative chemotherapy..
  • Any contraindication for FOLFIRI chemotherapy regimen.
  • Any investigational drug within the 30 days before inclusion.
  • Prior use of sunitinib or other multitarget tyrosine kinase inhibitors or VEGF pathway directed treatments like bevacizumab.
  • Known or suspected allergy or hypersensitivity reaction to any of the components of study treatments.
  • Pregnancy (absence to be confirmed by beta-hCG test) or lactation period
  • Men or women of child-bearing potential who are sexually active and unwilling to use a medically acceptable method of contraception during the trial
  • Clinically symptomatic brain or meningeal metastasis. (known or suspected)
  • Cardiac arrhythmias requiring anti-arhythmics (excluding beta blockers or digoxin).
  • History of any of the following cardiac events within the past 6 months:

    • myocardial infarction (including severe/ unstable angina),
    • coronary/peripheral artery bypass graft,
    • congestive heart failure (CHF),
    • cerebrovascular accident,
    • transient ischemic attack pulmonary embolism.
  • History of clinically significant bleeding within the past 6 months, including gross hemoptysis or haematuria, or underlying coagulopathy.
  • History of peptic ulcer disease, deep vein thrombosis, or other significant thrombo-embolic event within the past 6 months.
  • Uncontrolled severe hypertension (failure of diastolic blood pressure to fall below 90 mm Hg despite the use of >= 3 anti-hypertensive drugs.
  • Acute or sub-acute intestinal occlusion or history of inflammatory bowel disease or chronic diarrhea.
  • Previous malignancy (other than colorectal cancer) in the last 5 years except basal cell cancer of the skin, pre-invasive cancer of the cervix or superficial bladder tumor [Ta, Tis and T1].
  • History of organ allograft
  • Treatment with potent CYP3A4 inhibitor within 7 days of sunitinib/placebo dosing or with potent CYP3A4 inducer within 12 days of sunitinib/placebo dosing.
  • Prior full field radiotherapy =< 4 weeks, or limited field radiotherapy, =< to 2 weeks prior to study enrollment; or previous radiation treatment >30% of the bone marrow.
  • Major surgical procedure, open biopsy or significant traumatic injury within 4 weeks before starting treatment; anticipation of need for major surgical procedure (e.g. impending bowel obstruction) during the course of the study.
  • History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to study enrollment, unless affected area has been removed surgically.
  • Significant disease which, in the investigator's opinion would exclude the patient from the study.
  • Patients with seizure and epileptic disorder or other conditions requiring medication such as phenytoin, carbamazepin, phenobarbital.
  • Patients requiring long-term cortisone therapy.
  • Patients requiring oral anticoagulation treatment (marcoumar).
  • Known alcohol or drug abuse.
  • Medical or psychological conditions that would not permit the patient to complete the study or sign informed consent.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00806663

Locations
Germany
Innere Univ.-Klinik u. Poliklinik Tumorforschung
Essen, Germany, D-45122
Klinik für Tumorbiologie
Freiburg, Germany, D-79106
Medizinische Universitätsklinik der Albert-Ludwigs-Universität Freiburg
Freiburg, Germany, D-79106
Marienhospital
Herne, Germany, D-44625
Sponsors and Collaborators
Central European Society for Anticancer Drug Research
Investigators
Study Chair: Klaus Mross, MD Klinik für Tumorbiologie
  More Information

No publications provided

Responsible Party: Central European Society for Anticancer Drug Research
ClinicalTrials.gov Identifier: NCT00806663     History of Changes
Other Study ID Numbers: C-II-005 /2008-001515-37
Study First Received: December 10, 2008
Last Updated: September 7, 2012
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by Central European Society for Anticancer Drug Research:
mCRC
colorectal cancer
FOLFIRI
sunitinib
DCE-MRI
DCE-USI

Additional relevant MeSH terms:
Colorectal Neoplasms
Liver Neoplasms
Neoplasm Metastasis
Colonic Diseases
Digestive System Diseases
Digestive System Neoplasms
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Intestinal Diseases
Intestinal Neoplasms
Liver Diseases
Neoplasms
Neoplasms by Site
Neoplastic Processes
Pathologic Processes
Rectal Diseases
Sunitinib
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Antineoplastic Agents
Growth Inhibitors
Growth Substances
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses

ClinicalTrials.gov processed this record on October 23, 2014