The Combination Effect of Dexmedetomidine and Morphine in Postoperative Patient-Controlled Analgesia
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Purpose
This study was designed to examine the analgesic and side effects of dexmedetomidine-morphine mixture for intravenous patient-controlled analgesia (PCA).
| Condition | Intervention | Phase |
|---|---|---|
|
Analgesia, Patient-Controlled Analgesia, Postoperative |
Drug: dexmedetomidine |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator, Outcomes Assessor) Primary Purpose: Health Services Research |
| Enrollment: | 150 |
| Study Start Date: | November 2006 |
| Study Completion Date: | April 2008 |
Patient-controlled analgesia (PCA) is a widely accepted method to control postoperative pain. Morphine is the commonest opioid for PCA, however its side effects are troublesome. Morphine-related side effects include pruritus, nausea, vomiting, constipation, urinary retention, respiratory depression, and sedation. Many studies had been conducted to reduce the side effect of morphine. The current trend of reducing morphine side effect is direct combination of other drugs and morphine in PCA. The advantages of this method are convenient in clinical use and preventive for side effects. Dexmedetomidine is a highly selec¬tive α2-adrenergic receptor agonist that has been reported to cause sedative effects and reduce opioid requirements in the perioperative period. The main advantage of this drug is that it does not cause serious respiratory side effects. The analgesic, sedative/hypnotic and anxiolytic prop¬erties of dexmedetomidine make this drug potentially useful for postoperative sedation and analgesia. No previous study had investigated the effect of direct combination of dexmedetomidine and morphine in PCA. The goal of this study is to investigate the combination effect of dexmedetomidine and morphine in postoperative patient-controlled analgesia.
Eligibility| Ages Eligible for Study: | 18 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients who sign informed consent to receive general anesthesia and postoperative analgesia with a PCA device
- Age between 18-65 y/o
- ASA physical status I-III
- Scheduled surgical procedures: gynecological surgery (vaginal or abdominal total hysterectomy), general surgery (gastrectomy, hepatectomy, colon cancer) , orthopedic (spinal fusion or total knee placement), or neurosurgical (cervical decompression)
Exclusion Criteria:
- Patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, NSAIDs, sedatives, antidepressants).
- Use of sedatives, analgesics, antiemetics, or antipruritics within 24 hours before operation.
- Patients with definite diagnosis of esophageal reflux syndrome.
- Patients with the probability to be pregnant.
- Intraoperative fentanyl use > 6 μg/kg.
- Patients with significant bradycardia (HR < 60/min) and hypotension (SBP < 90mmHg) after the surgery.
- The duration of surgery is longer than 6 hours.
Contacts and Locations More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00800826 History of Changes |
| Other Study ID Numbers: | 950910 |
| Study First Received: | December 1, 2008 |
| Last Updated: | December 1, 2008 |
| Health Authority: | Taiwan: Department of Health |
Additional relevant MeSH terms:
|
Dexmedetomidine Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents Therapeutic Uses Analgesics, Non-Narcotic Analgesics |
Sensory System Agents Peripheral Nervous System Agents Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action |
ClinicalTrials.gov processed this record on May 21, 2013