Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy (EchoSpA)
Recruitment status was Active, not recruiting
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Purpose
The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis
| Condition |
|---|
|
Spondylarthropathy Ankylosing Spondyloarthitis Spondyloarthritis |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy in Patients With Uncertain Diagnosis Consulting for Clinical Symptoms Suggestive of Spondylarthropathy |
whole blood
| Enrollment: | 489 |
| Study Start Date: | January 2005 |
| Estimated Study Completion Date: | September 2009 |
| Primary Completion Date: | September 2007 (Final data collection date for primary outcome measure) |
Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients with a symptomatology which can lead to a SPA diagnosis but with no confirmed diagnosis yet for any rheumatic didease.
Inclusion Criteria:
- patients < 50 years old, consulting for spinal inflammatory symptoms > 3 months duration
- patients consulting for arthritis or tenderness joints > 3 months duration
- patients < 50 years old consulting for enthesitis or dactylitis > 3 months duration
- patients with uveitis and HLA-B27 positivity
- relatives of SpA patients consulting for symptoms suggestive of SpA
Exclusion Criteria:
- patient with confirmed diagnosis of rheumatic disease (included SpA)
- patient protected by law (patient <18 years old, pregnant woman)
- patient who can't atempt the RMI
- patient who will have difficulties to complete the two years of follow-up
Contacts and Locations| France | |
| Ambroise Paré Hospital | |
| Boulogne Billancourt, France, 92100 | |
| Cavale Blanche Hospital | |
| Brest, France, 29200 | |
| Cote de Nacre Hospital | |
| Caen, France, 14033 | |
| South Hospital of Grenoble | |
| Echirolles, France, 38434 | |
| Conception Hospital | |
| Marseille, France, 13005 | |
| Nancy Brabois Hospital | |
| VANDOEUVRE les NANCY, France, 54511 | |
| Principal Investigator: | D'AGOSTINO Maria-Antonietta, MCUPH | Ambroise Paré Hospital |
More Information
No publications provided by Groupe Français d'Etude Génétique des Spondylarthropathies
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | D'AGOSTINO Maria Antonietta, MCUPH, GESPA |
| ClinicalTrials.gov Identifier: | NCT00794404 History of Changes |
| Other Study ID Numbers: | GESPA |
| Study First Received: | November 19, 2008 |
| Last Updated: | November 19, 2008 |
| Health Authority: | France: Ministry of Health |
Additional relevant MeSH terms:
|
Spondylarthritis Spondylarthropathies Spondylitis Spinal Diseases |
Bone Diseases Musculoskeletal Diseases Arthritis Joint Diseases |
ClinicalTrials.gov processed this record on May 16, 2013