Insulin Resistance and Substrate Metabolism After Acute Erythropoietin (EPO) Administration
Recently EPO receptors have been found in human muscle tissue, but what is still not known is the physiological role of these receptors. In this study the researchers want to investigate if there is any effect of a acute administration of EPO on insulin resistance and/or substrate metabolism in muscle tissue.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
|Official Title:||Insulin Resistance and Substrate Metabolism After Acute EPO Administration in Healthy Young Men|
- Insulin sensitivity [ Time Frame: 4 and 6 hours post ] [ Designated as safety issue: No ]
- Substrate metabolism [ Time Frame: 4 and 6 hours post ] [ Designated as safety issue: No ]
|Study Start Date:||January 2009|
|Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
Placebo Comparator: placebo
Drug: placebo (saline)
acute administration of erythropoietin
bolus of 400 IU/kg
Recently EPO receptors have been found in human muscle tissue, but what is still not known is what the physiological role of these receptors are. It has previously been shown that Growth Hormone mediate insulin resistance. The GH receptor and EPO receptor belong to the same family of cytokine receptors, and thereby share many of the same signalling pathways. In this study we want to investigate if there is a similar effect on insulin resistance and/or substrate metabolism after acute administration of EPO in human muscle tissue. Different signalling pathways are investigated på western blotting, and insulin sensitivity are measured be a hyperinsulinemic euglycemic clamp, and substrate metabolism is measured by the forearm model.