This is a pilot study to determine whether changes in tissue oxygenation, oxygen metabolism, and indicators of tissue damage can non-invasively be quantified using DOS in patients with Metabolic Syndrome, patients with both Type I DM, Type II DM, and in non-diseased subjects.
Primary Outcome Measures:
- To monitor microvascular changes in patients with Metabolic Syndrome and with DM to assess their disease progression and cardiovascular risks. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||November 2013 (Final data collection date for primary outcome measure)
Device: Diffuse Optical Spectroscopy
The researchers want to use DOS as a means to monitor changes in the microvasculature of patients with Metabolic Syndrome and DM, and patients with DPN, versus non-diseased and predisposed subjects by evaluating the changes in oxygen metabolism. This will be done by measuring the changes in the concentration and oxygen saturation of hemoglobin in the microvasculature under stress, for example, during exercise and in response to changes in breathing habits. The sensitivity of DOS to tissue hemodynamics provides an impressive arena of useful clinical applications..