• Improvement in the condition of the ulcer as judged by comparative photography and independent clinical assessment [ Time Frame: 10 Days ] [ Designated as safety issue: No ]
• Incidence of adverse events [ Time Frame: 10 Days ] [ Designated as safety issue: Yes ]

The purpose of the study is to determine if topically applied nitric oxide gas is effective in reducing the quantity of bacteria (including MRSA)in a wound.

• Skin Ulcers
• Methicillin-resistant Staphylococcus Aureus Infection

Inclusion Criteria:

• Must have given written informed consent
• Must be ≥ 18 years of age and not of child bearing potential
• Must have an ulcer in which the presence of MRSA has been identified, but which is not clinically infected
• Must have an ulcer size not to extend beyond the inner borders of the dressing

Exclusion Criteria:

• Is a female of child bearing years or who could become pregnant
• Is < 18 years of age
• Has an clinically infected skin ulcer
• Has a ulcer that is being treated with a topical antimicrobial agent or has been treated with a topical antimicrobial agent during 3 days prior to enrolment
• Has been using systemic antibiotics during 7 days prior to enrolment into this study
• Has an ulcer which is identified as malignant in origin (e.g. Marjolin's ulcer)
• Has an ulcer size beyond the inner borders of the dressing
• Is septic or has other signs of an invasive infection
• Has used any investigational drug within 30 days preceding study participation.
• Suffers from a condition, which, in the opinion of the Investigator, would compromise his or her safety.
• Suffers from a condition which, in the opinion of the Investigator, would compromise the quality of the data.
• Has a known allergy to any of the products that are part of this protocol
• Suffers from a condition which, in the opinion of the Investigator, would seriously interfere negatively with the normal parameters of immune response to an infection.
• Is using any of the prohibited concomitant medications or treatments