Analysis of Cortical Excitability in Neuropathic Pain
Recruitment status was Recruiting
The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Analysis of Cortical Excitability in Neuropathic Pain: an Electrophysiology Study.|
- Abnormal cortical excitability in motor-sensory cross-talk [ Time Frame: non-applicable ] [ Designated as safety issue: No ]
- Genetic variability of neurotrophic factors between groups [ Time Frame: non-applicable ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Genomic polymorphism of neurotrophic factors.
|Study Start Date:||October 2008|
|Estimated Study Completion Date:||October 2011|
|Estimated Primary Completion Date:||October 2011 (Final data collection date for primary outcome measure)|
Patient with neuropathic pain
patients without neuropathic pain
There are several brain areas responsible for neuropathic pain reported in functional image studies, including primary sensory cortex, insula, and anterior cingulate gyrus. However, it is few informations about the functional status of these areas. Besides, the reason of the individual variability about the developement of neuropathic pain remains unknown. It is lack of satisfactory explanation about why some people developed neuropathic pain in certain diseased situation (for example, type 2 diabetes), while others do not.
We hypothesis that patients with neuropathic pain has abnormal cortical excitability and plasticity in certain brain area. Therefore developed neuropathic pain certain diseased condition while others not. Therefore, we will use multimodal electrophysiology tools,such as transcranial magnetic stimulation, peripheral nerve stimulation, and contact heat evoke potential to monitor the cortical excitability and plasticity non-invasively.
|Contact: Ming-Kai Pan, M.D.||886-2-23123456 ext firstname.lastname@example.org|
|Contact: Ch-Chao Chao, M.D.||886-2-23123456 ext email@example.com|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Ming-Kai Pan, M.D. 886-2-23123456 ext 9803397 firstname.lastname@example.org|
|Contact: Chi-Chao Chao, M.D. 886-2-23123456 ext 9801967 email@example.com|
|Sub-Investigator: Ming-Kai Pan, M.D.|
|Principal Investigator: Sung-Tsang Hsieh, M.D. PhD|
|Sub-Investigator: Chi-Chao Chao, M.D.|
|Study Director:||Ming-Kai Pan, M.D.||National Taiwan University Hospital, Department of Neurology|
|Study Director:||Chi-Chao Chao, M.D.||National Taiwan University Hospital, Department of Neurology|
|Principal Investigator:||Sung-Tsang Hsieh, M.D. PhD||National Taiwan University Hospital, Department of Neurology|