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Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort

This study has been completed.
Sponsor:
Collaborators:
Beckman Laser Institute University of California Irvine
University of California, Irvine
Information provided by (Responsible Party):
Montana Compton, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00786721
First received: November 4, 2008
Last updated: October 28, 2011
Last verified: October 2011
History of Changes
  Purpose

There has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus and the overlapping Metabolic Syndrome.


Condition Intervention
Metabolic Syndrome
Type 2 Diabetes Mellitus
 Device: Diffuse Optical Spectroscopy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Diffuse Optical Spectroscopy Measurement Technique is Helping Develop More Effective Diagnostic Tools and Therapeutic Regimes for Diabetes, Metabolic Syndrome and Other Mitochondrial Diseases Some Time in the Future

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of California, Irvine:

Primary Outcome Measures:
  • Near Infrared Spectroscopy to assess muscle mitochondrial OXPHOS function. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]

Enrollment: 9
Study Start Date: November 2006
Study Completion Date: August 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Diagnosis
muscle weakness
 Device: Diffuse Optical Spectroscopy
muscle properties scanning

Detailed Description:

Once the mitochondrial defect(s) of these subjects has been defined, the data will be used to develop two non-invasive screening tools to detect mitochondrial defects in Diabetes Mellitus and Metabolic Syndrome patients.

The device call Diffuse Optical Spectroscopy develope at Beckman Laser Instituteis is non-invasive measurement technique, to measure the properties of the muscle tisuue and vascular activity (calf, bicep, or the brain)to evaluate the patient's metabolic status and and to assess muscle mitochondrial OXPHOS function.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

primary care clinic, community sample, residents in a Southern California Chinese Cohort

Criteria

Inclusion Criteria:

  • Chinese descent and have been clinically diagnosed with diabetes mellitus (DM) or have met the study criteria for metabolic syndrome (MS).

Exclusion Criteria:

  • non chiness descent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00786721

Locations
United States, California
Beckman Laser Institute Medical clinic
Irvine, California, United States, 92612
Sponsors and Collaborators
Montana Compton
Beckman Laser Institute University of California Irvine
University of California, Irvine
Investigators
Principal Investigator: Bruce J Tromberg, PhD Beckman Laser Institute University of California Irvine
Principal Investigator: Douglas c Wallace, PhD UCI, Molecular and Mitochondrial medicine and Genetics
  More Information

No publications provided

Responsible Party: Montana Compton, Administrative Nurse Research Coordinator Beckman Laser Institute, University of California, Irvine
ClinicalTrials.gov Identifier: NCT00786721     History of Changes
Other Study ID Numbers: LAMMP DOS-01192-29
Study First Received: November 4, 2008
Last Updated: October 28, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Irvine:
Mitochondria and Metabolic Syndrome

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Metabolic Syndrome X
Mitochondrial Diseases
Glucose Metabolism Disorders
 Metabolic Diseases
Endocrine System Diseases
Insulin Resistance
Hyperinsulinism

ClinicalTrials.gov processed this record on May 16, 2013