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Evaluation of Skeletal Muscle Lipid Content by Magnetic Resonance Spectroscopy

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
National Center for Research Resources (NCRR)
Information provided by (Responsible Party):
University of Minnesota - Clinical and Translational Science Institute
ClinicalTrials.gov Identifier:
NCT00786578
First received: November 5, 2008
Last updated: February 5, 2013
Last verified: February 2013
History of Changes
  Purpose

Type 2 diabetes is a growing public health issue and one component of Type 2 diabetes is 'insulin resistance" - the ability of insulin to work less well. The skeletal muscle is one of the largest users of sugar in the body, when the skeletal muscle is "insulin resistant", this contributes to diabetes. There is some evidence that the amount of fat in the skeletal muscle is related to the amount of insulin resistance. We are asking people to participate in a study to look at the amount of fat in muscle and how this fat amount changes with exercise. We hypothesize that heavier people will have higher amounts of fat and deplete this fat more slowly than lean subjects.


Condition
Healthy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Evaluation of Intramyocellular Lipid Content (IMCL) in Skeletal Muscle by Magnetic Resonance Spectroscopy

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Minnesota - Clinical and Translational Science Institute:

Primary Outcome Measures:
  • absolute change in intramyocellular lipid quantity with exercise [ Time Frame: over 4 months ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

blood will be sampled and retained for future metabolic testing as needed


Estimated Enrollment: 14
Study Start Date: January 2010
Estimated Study Completion Date: January 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
overweight runners (BMI>25)
2
lean runners (BMI<24)

Detailed Description:

High intramyocellular lipid (IMCL) content in skeletal muscle has been correlated to insulin resistance in obese subjects. Yet, endurance athletes have high intramyocellular lipid content and very low insulin resistance. There are several explanations for this paradox. This study will use a new magnetic resonance imaging technique to look at the amount of fat in the muscle and its depletion with exercise. We hypothesize that overweight subjects will have higher amounts of fat and deplete this fat more slowly than lean subjects.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy subjects on regular running program.

Criteria

Inclusion Criteria:

  • Age range will be from age 18 to 45. We will be limiting the upper age range because increased age is associated with sarcopenia and alteration of fiber type.
  • We will define the lean trained group by a BMI of < 24 kg/m2. We will define the overweight group as BMI > 26 25 kg/m2.
  • The subjects should be participating in regular running exercise (> 30 min/day, ≥ 5 days/week).
  • Weight must be stable [+/- 5 pounds] for at least the three months prior to the study for all participants.

Exclusion Criteria:

  • The subjects must not be on medications that may affect lipid levels, specifically lipid lowering agents, birth control pills, or diuretics.
  • The subjects should not be on a high fat diet (> 45% fat) as measured by a screening questionnaire.
  • The subject must not have any contraindications to magnetic resonance imaging.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00786578

Locations
United States, Minnesota
Univeresity of Minnesota
Minneapolis, Minnesota, United States, 55455
Sponsors and Collaborators
University of Minnesota - Clinical and Translational Science Institute
National Center for Research Resources (NCRR)
Investigators
Principal Investigator: Lisa S Chow University of Minnesota - Clinical and Translational Science Institute
  More Information

No publications provided

Responsible Party: University of Minnesota - Clinical and Translational Science Institute
ClinicalTrials.gov Identifier: NCT00786578     History of Changes
Other Study ID Numbers: 0708M13941, 5K12RR023247-02
Study First Received: November 5, 2008
Last Updated: February 5, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Minnesota - Clinical and Translational Science Institute:
training
intramyocellular lipid
insulin resistance

ClinicalTrials.gov processed this record on May 21, 2013