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Mitochondria Inborn Errors of Metabolism and ANT Defects in Mitochondria Diseases

This study is enrolling participants by invitation only.
Sponsor:
Collaborators:
Beckman Laser Institute University of California Irvine
University of California, Irvine
Information provided by (Responsible Party):
Montana Compton, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00786539
First received: November 4, 2008
Last updated: December 26, 2012
Last verified: December 2012
History of Changes
  Purpose

The objective of this research protocol is to continue investigation of the nature and prevalence of mitochondria disease and to aid patients and health care providers in the understanding of these complex disorders.

This research study brings together many clinical sub-specialists to address the etiology of these disorders and to develop more effective approaches for their diagnoses and more reliable prognoses.


Condition Intervention
Mitochondrial Disease
 Device: Diffuse Optical Spectroscopy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Investigation of the Nature and Prevalence of Mitochondria Disease

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of California, Irvine:

Primary Outcome Measures:
  • to develop more effective approaches for their diagnoses and more reliable prognoses [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 50
Study Start Date: October 2006
Estimated Study Completion Date: October 2015
Estimated Primary Completion Date: October 2015 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: Diffuse Optical Spectroscopy
    mitochondria
Detailed Description:

The non-invasive device named Diffuse Optical Spectroscopy developed at the Beckman Laser Institute is to be used to measure various physiological parameters. Since mitochondria produce most of the energy necessary for cellular function, their efficacy is most important for systems with a high energy demand like the brain, heart, skeletal muscle, kidney, liver, and endocrine tissues. As a result, mitochondria diseases usually manifest as complex, multi-organ disorders, requiring multispecialty investigations.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

primary care clinic, community sample

Criteria

Inclusion Criteria:

  • Subjects with mitochondrial disorder

Exclusion Criteria:

  • Subjects with visual, auditory and/or neurological problems known to result from toxic or environmental effects
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00786539

Locations
United States, California
Beckman Laser Institute Medical clinic
Irvine, California, United States, 92612
Sponsors and Collaborators
Montana Compton
Beckman Laser Institute University of California Irvine
University of California, Irvine
Investigators
Principal Investigator: Bruce J Tromberg, PhD Beckman Laser Institute University of California Irvine
Principal Investigator: Jay Gargus c Gargus, MD, PhD UCI, Molecular and Mitochondrial medicine and Genetics
  More Information

No publications provided

Responsible Party: Montana Compton, Administrative Nurse Research Coordinator Beckman Laser Institute, University of California, Irvine
ClinicalTrials.gov Identifier: NCT00786539     History of Changes
Other Study ID Numbers: LAMMP-DOS-01192-29
Study First Received: November 4, 2008
Last Updated: December 26, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Irvine:
mitochondrial

Additional relevant MeSH terms:
Metabolism, Inborn Errors
Mitochondrial Diseases
Genetic Diseases, Inborn
Metabolic Diseases

ClinicalTrials.gov processed this record on May 22, 2013