Measurement of the Eye's Blood Vessels Using the Dynamic Vessel Analyzer (DVA)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this research study is examine the response of the blood vessels in the eye to a light flicker stimulus using the Dynamic Vessel Analyzer (DVA) on two separate days in healthy individuals. The DVA uses an instrument which is used during routine eye examinations. The hypothesis of the study is that the changes in eye's blood vessel will be similar between the two visits; thus establishing reproducibility of the measurements for future comparisons to individuals with stroke or heart disease. In addition, this study will compare the eye's blood vessel responses to responses of the blood vessels in the arm using Doppler ultrasound.
| Condition |
|---|
|
Healthy |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Reproducibility of Dynamic Vessel Analyzer Measurements and Establishment of Standards |
- To characterize changes in the diameter of retinal blood vessels to a light-induced flicker stimulus in healthy subjects on two separate visits. [ Time Frame: 1 Year ] [ Designated as safety issue: No ]
- To compare retinal vasodilator responses to brachial reactive hyperemic responses. [ Time Frame: 1 Year ] [ Designated as safety issue: No ]
| Enrollment: | 87 |
| Study Start Date: | October 2008 |
| Study Completion Date: | December 2011 |
| Primary Completion Date: | December 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Healthy Subjects
Healthy participants between the ages of 21 and 65 years old.
|
Detailed Description:
Retinal blood vessels have been suggested to be an index of the cerebral and coronary microvasculature function. Since the retinal vessels are not under direct sympathetic control, this vascular bed is an ideal location to examine local mechanisms of vascular regulation(i.e. metabolite/endothelial and myogenic). Based on previously published data on animal and human responses, the central purpose for the proposed research is to compare the retinal and brachial vasodilatation responses in healthy subjects using the Dynamic Vessel Analyzer (DVA). Our rationale for this proposal is to better understand retinal blood flow in healthy individuals, gain insight into vascular reactivity in different vascular beds, and lastly to establish standards and reproducibility of DVA Measurements.
Eligibility| Ages Eligible for Study: | 21 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Healthy Subjects
Inclusion Criteria:
- Healthy Individuals
- Age: 21 to 65 years
- Non-smokers
- Non-obese
Exclusion Criteria:
- History of cardiovascular, pulmonary, peripheral vascular disease, renal, prostate, and urinary retention disease; Hypertension; Narrow angle Glaucoma or Age Related Macular Degeneration.
- Pregnancy
- Inability to fixate using eye device
- Does not wish to participate
Contacts and Locations| United States, Pennsylvania | |
| Penn State Milton S. Hershey Medical Center | |
| Hershey, Pennsylvania, United States, 17033 | |
| Principal Investigator: | Kerstin Bettermann, MD, PhD | Penn State College of Medicine |
More Information
No publications provided
| Responsible Party: | Kerstin Bettermann, MD, PhD, Penn State University |
| ClinicalTrials.gov Identifier: | NCT00783029 History of Changes |
| Other Study ID Numbers: | HMC29113, IRB # 29113 |
| Study First Received: | October 30, 2008 |
| Last Updated: | February 6, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Penn State University:
|
Vasodilation Vessel Reactivity Dynamic Vessel Analyzer Retina |
ClinicalTrials.gov processed this record on May 16, 2013