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C-Reactive Protein (CRP) Gene Variants and Coronary Artery Disease in a Chinese Han Population (CRP-Han)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2008 by Fudan University.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Fudan University
ClinicalTrials.gov Identifier:
NCT00780221
First received: October 24, 2008
Last updated: NA
Last verified: October 2008
History: No changes posted
  Purpose

The recognition of the association between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD) has led to an increased emphasis on CRP genetic effects on CRP level and CHD. However, the causality of CRP variants remains uncertain.The objective of this study is to evaluate the association of CRP gene variants and CRP levels in CHD in Chinese Han population. We conduct case-control study in CRP-Han study participants. The common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels are detected. A Mendelian randomization analysis will be used to help test the likelihood of causal association of gene-CRP levels, CRP levels-CHD and gene-CHD. The investigators hypothesize that CRP gene variants influence the protein level and may participate in CHD progress.


Condition
Coronary Artery Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: CRP Gene Variants and Coronary Artery Disease in a Chinese Han Population

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Fudan University:

Biospecimen Retention:   Samples With DNA

Blood sample will be examined and DNA variants be analyzed.


Estimated Enrollment: 1000
Study Start Date: October 2008
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
control
patients without coronary artery disease
case
patients with coronary artery disease

Detailed Description:

CHD patients and non-CHD population are recruited. CRP level and CHD severity by coronary angiograph will be examined. Mendelian randomization analysis are taken to analyze statically.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

in-hospital patients and community healthy individual

Criteria

Inclusion Criteria:

  • clinical diagnosis of coronary artery disease

Exclusion Criteria:

  • with major organ disfunction or acute inflammatory disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00780221

Contacts
Contact: Chaoneng Wu, PhD +86-21-64041990 ext 2152 wuchaoneng@hotmail.com

Locations
China, Shanghai
Zhongshan Hospital Recruiting
Shanghai, Shanghai, China, 200032
Contact: Chaoneng Wu     +86-21-64041990 ext 2152     wuchaoneng@hotmail.com    
Sub-Investigator: Chaonneg Wu, PhD            
Principal Investigator: Junbo Ge, PhD,MD            
Sponsors and Collaborators
Fudan University
Investigators
Study Director: Junbo Ge Zhongshan Hospital
  More Information

No publications provided

Responsible Party: Zhongshan Hospital, Shanghai Institute of Cardiovascular Disease,Zhongshan Hospital
ClinicalTrials.gov Identifier: NCT00780221     History of Changes
Other Study ID Numbers: ZSJQ-30725036, 30725036
Study First Received: October 24, 2008
Last Updated: October 24, 2008
Health Authority: China: National Natural Science Foundation

Keywords provided by Fudan University:
CRP
coronary artery disease
polymorphisms

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
 Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on May 16, 2013