Impact of Preoperative Chemotherapy on Complications and Regeneration After Resection of Colorectal Liver Metastases

This study has been completed.
Sponsor:
Information provided by:
University of Zurich
ClinicalTrials.gov Identifier:
NCT00779272
First received: October 23, 2008
Last updated: NA
Last verified: October 2008
History: No changes posted
  Purpose

The objective of this study is to evaluate for the first time not only the impact of neoadjuvant chemotherapy on clinical outcome, but also on liver regeneration after liver resection.


Condition
Colorectal Liver Metastases

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Impact of Preoperative Chemotherapy on Complications and Regeneration After Resection of Colorectal Liver Metastases

Resource links provided by NLM:


Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Postoperative Complications and liver regeneration [ Time Frame: 2003- July 2008 ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 184
Study Start Date: September 2008
Study Completion Date: October 2008
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Without preoperative chemotherapy
2
With preoperative chemotherapy

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Records from 184 consecutive patients undergoing liver resection due to colorectal metastases between 2003 and July 2008 were reviewed from a prospective database

Criteria

Inclusion Criteria:

  • Liver resection due to colorectal liver metastases between 2003 and 2007

Exclusion Criteria:

  • Incomplete assessment of preoperative chemotherapy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00779272

Locations
Switzerland
Departement of Visceral and Transplantation Surgery of the University of Zurich
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
  More Information

No publications provided

Responsible Party: Breitenstein Stefan, Dr. med., Department Visceral and Transplantation Surgery, University Hospital of Zurich
ClinicalTrials.gov Identifier: NCT00779272     History of Changes
Other Study ID Numbers: StV 29-2008
Study First Received: October 23, 2008
Last Updated: October 23, 2008
Health Authority: Switzerland:Ethic Committee Kanton Zurich

Keywords provided by University of Zurich:
neoadjuvant chemotherapy
clinically postoperative outcome
liver regeneration after liver resection

Additional relevant MeSH terms:
Neoplasm Metastasis
Neoplasms, Second Primary
Liver Neoplasms
Neoplastic Processes
Neoplasms
Pathologic Processes
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases

ClinicalTrials.gov processed this record on July 20, 2014