Neuropsychological and Behavioral Testing in Young Patients With Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor (PNET)
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Purpose
RATIONALE: Collecting information over time from a series of tests may help doctors develop effective tests to measure neuropsychological and behavioral function in young patients with cancer.
PURPOSE: This clinical trial is studying neuropsychological and behavioral testing in young patients with medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET).
| Condition | Intervention |
|---|---|
|
Brain and Central Nervous System Tumors Chemotherapeutic Agent Toxicity Cognitive/Functional Effects Neurotoxicity Psychosocial Effects of Cancer and Its Treatment Radiation Toxicity Therapy-related Toxicity |
Other: questionnaire administration Procedure: cognitive assessment Procedure: psychosocial assessment and care Procedure: quality-of-life assessment |
| Study Type: | Observational |
| Official Title: | Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer |
- Consistent, streamlined, and efficient administration of neuropsychological and behavioral tests [ Designated as safety issue: No ]
- Utilization of standardized battery of age-appropriate neuropsychological and behavioral tests in conjunction with COG Phase III clinical trials [ Designated as safety issue: No ]
| Estimated Enrollment: | 755 |
| Study Start Date: | September 2008 |
| Estimated Primary Completion Date: | October 2012 (Final data collection date for primary outcome measure) |
OBJECTIVES:
- To institute procedures to ensure a consistent, streamlined, and efficient administration of the neuropsychological and behavioral tests in a cooperative group setting in order to maximize compliance with a standardized assessment battery conducted at 3 standardized time points in children with medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET).
- To utilize a standardized battery of age-appropriate neuropsychological and behavioral tests in conjunction with COG Phase III clinical trials to evaluate cognitive, social, emotional, and behavioral functioning over time.
OUTLINE: This is a multicenter study.
Parent and child participants complete the COG Standard Neuropsychological and Behavioral Battery testing at 9, 30, and 60 months post-diagnosis in a 1-hour session conducted by a neuropsychologist or psychologist. The Battery consists of tests of intelligence, processing speed/attention, memory, language preference, general developmental progress, attention and behavior/social/emotional function, executive function, adoptive function, and quality of life. Additionally, parents complete a parent-report questionnaire to gather information about patient's function in terms of attention, memory, executive abilities, and behavioral, social, and emotional adaption.
Eligibility| Ages Eligible for Study: | 3 Years to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
- Histologically confirmed diagnosis of medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET)
- Must be currently enrolled on a COG therapeutic study that aims to examine neuropsychological, social, emotional, and/or behavioral functioning
PATIENT CHARACTERISTICS:
- Must have receptive and expressive English language skills
Patients with a history of severe or profound mental retardation (i.e., IQ < 50) are not eligible for enrollment
- Children with a prior history of attention-deficit hyperactivity disorder (ADHD) or a specific learning disability (e.g., dyslexia) are eligible for this study
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Contacts and Locations
Show 119 Study Locations| Study Chair: | Leanne E. Segovia, PhD | CHRISTUS Santa Rosa Children's Hospital |
More Information
Additional Information:
No publications provided
| ClinicalTrials.gov Identifier: | NCT00772200 History of Changes |
| Other Study ID Numbers: | CDR0000594326, COG-ALTE07C1 |
| Study First Received: | October 14, 2008 |
| Last Updated: | October 26, 2012 |
| Health Authority: | Unspecified |
Keywords provided by National Cancer Institute (NCI):
|
chemotherapeutic agent toxicity neurotoxicity radiation toxicity therapy-related toxicity cognitive/functional effects |
psychosocial effects of cancer and its treatment recurrent childhood medulloblastoma untreated childhood medulloblastoma recurrent childhood supratentorial primitive neuroectodermal tumor untreated childhood supratentorial primitive neuroectodermal tumor |
Additional relevant MeSH terms:
|
Medulloblastoma Nervous System Neoplasms Central Nervous System Neoplasms Neuroectodermal Tumors Neuroectodermal Tumors, Primitive Neurotoxicity Syndromes Radiation Injuries Glioma Neoplasms, Neuroepithelial Neoplasms, Germ Cell and Embryonal |
Neoplasms by Histologic Type Neoplasms Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms by Site Nervous System Diseases Poisoning Substance-Related Disorders Wounds and Injuries |
ClinicalTrials.gov processed this record on May 23, 2013