Septic Encephalopathy and Late Cognitive Dysfunction
Delirium and long-term cognitive dysfunction are important problems in intensive care patients. Patients with sepsis are at a high risk of developing delirium (septic encephalopathy), which may be an important risk factor for the development of long-term cognitive dysfunction.
Working hypotheses: 1. Septic encephalopathy and cognitive dysfunction are caused by an unspecific reaction of the brain to an intense inflammatory stimulus. 2. It is possible to therapeutically influence the inflammatory response and its effects on the brain.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:||Septic Encephalopathy and Late Cognitive Dysfunction in Patients With Sepsis - the Role of Inflammation|
|University Hospital Basel|
|Basel, Switzerland, 4031|
|Principal Investigator:||Luzius A Steiner, MD, PhD||Department of Anaesthesia, University Hospital Basel, Switzerland|