Osteoarthritis and Body Composition: Evaluation of Systematic Mediators
The purpose of this study is to examine the relationship between body composition and knee osteoarthritis, and effects of inflammatory, metabolic, and hormonal factors.
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Osteoarthritis and Body Composition: Evaluation of Systematic Mediators|
- Changes in inflammatory marker c-reactive protein [ Time Frame: 3 to 5 years ] [ Designated as safety issue: No ]
- Changes in other biomarkers: inflammatory, metabolic, bone, and joint [ Time Frame: 3 to 5 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Banked serum and urine samples
|Study Start Date:||January 2003|
|Estimated Study Completion Date:||December 2012|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Banked serum and urine specimens obtained from NIA Baltimore Longitudinal Study on Aging (BLSA) participants with and without knee OA will be used to determine inflammatory, metabolic, bone and joint biomarkers in an observational, case-control study. This study will be limited to BLSA data and samples that have already been acquired and stored.
The specific aims of this study are to:
- Examine the association between prevalent radiographic osteoarthritis (OA), concurrently obtained inflammatory and metabolic mediator levels and change in bone density and bone markers over time subsequent to radiographic classification.
- Determine levels of inflammatory, metabolic and bone markers, and body composition when radiographic OA was absent, and examine their relationship to the development of radiographic knee OA.
Adjustments will be made for age, gender, body mass index and level of physical activity.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00771082
|United States, Maryland|
|National Institute on Aging|
|Baltimore, Maryland, United States, 21225|
|Principal Investigator:||Shari Ling, MD||National Institute on Aging (NIA)|