CC-4047 (Pomalidomide) for Graft vs. Host Disease

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT00770757
First received: October 7, 2008
Last updated: August 9, 2013
Last verified: August 2013
  Purpose

This study will test the safety and effectiveness CC-4047 (pomalidomide) in patients with advanced, steroid refractory graft-versus-host disease.


Condition Intervention Phase
Graft vs Host Disease
Drug: CC-4047
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase 2, Open-Label, Single-Arm, Pilot Study of Safety and Efficacy of CC-4047 (Pomalidomide) in Patients With Advanced Chronic Graft-Versus-Host Disease Developing After Allogeneic Hematological Stem Cell Transplantation

Resource links provided by NLM:


Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • Efficacy of CC-4047 [ Time Frame: 1 year after last dose of CC-4047 ] [ Designated as safety issue: No ]
    Overall response (complete response, partial response based on NIH Consensus Response Criteria Working Group)


Secondary Outcome Measures:
  • Safety of CC-4047 [ Time Frame: 30 days after last dose of CC-4047 or until resolution of event ] [ Designated as safety issue: Yes ]
    Safety (type, frequency, severity, and relationship to CC-4047)


Enrollment: 13
Study Start Date: February 2009
Study Completion Date: October 2011
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: CC-4047 Arm
CC-4047 2 mg orally every day for 1 course (12 weeks or 84 days). Every 28 days of treatment are considered as 1 cycle and every 3 cycles are are considered as 1 course of treatment. A total of 4 courses of treatment are planned (12 months).
Drug: CC-4047
Other Name: Pomalidomide

Detailed Description:

Chronic Graft vs. Host Disease is a major complication after allogeneic hematopoietic stem cell transplantation developing in 30 - 70% of patients. It is a multisystem alloimmune and autoimmune disorder with a negative impact on quality of life and functional status, increased need for extended immunosuppression and is the leading cause of late transplant related mortality.

CC-4047 is a novel immune modulatory drug that is a thalidomide analog with a 4,000 fold greater inhibition of TNF-α production related to thalidomide. Several features of CC-4047 suggest that this drug may be useful in treating chronic GVHD including in vitro suppression of TNF-α production, increasing Th1 and stimulation of IL-12 and sIL-Rα.

This study is a phase 2, open-label, single-arm, pilot study of efficacy and safety of CC-4047 in patients with advanced chronic GvHD who failed to achieve a response with high-dose corticosteroids or second line systemic immunosuppressive therapy.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Patient must meet all of the following inclusion criteria:

  • Must be greater than or equal to 18 years of age at the time of consent.
  • Must be able to adhere to the study visit schedule and other protocol requirements.
  • Chronic graft versus host disease (GHVD) developing after allogeneic hematological stem cell transplantation diagnosed using NIH criteria for diagnosis and staging of chronic GvHD (including both "classic chronic GvHD" and "overlap syndrome")
  • Must have moderate or severe chronic GvHD according to Global Staging System for Chronic GvHD or mild chronic GvHD with platelet count less than 100 x 109/L
  • Must have failed to achieve response to high dose corticosteroid (average 0.5 mg/kg/day prednisone or equivalent for greater than or equal to 8 weeks), or have failed second line systemic immunosuppressive therapy.
  • If taking corticosteroids at the time of enrollment, must be on stable or tapering schedule without corticosteroid pulses in the preceding 8 weeks.
  • If taking secondary systemic immunosuppressive therapy at the time of enrolment, must be on stable or tapering schedule in the preceding 4 weeks.
  • Karnofsky performance score (KPS) greater than or equal to 60%.
  • Life expectancy greater than or equal to 3 months.
  • Female of childbearing potential (FCBP) must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual intercourse for at least 28 days before starting study drug, while participating in the study, and for at least 28 days after discontinuation from the study. The two methods of reliable contraception must include one highly effective method (i.e. intrauterine device (IUD), hormonal [birth control pills, injections, or implants], tubal ligation, partner's vasectomy) and one additional effective (barrier) method (i.e. latex condom, diaphragm, cervical cap). FCBP must be referred to a qualified provider of contraceptive methods if needed.
  • FCBP must agree to pregnancy testing and contraceptive counseling every 28 days during the study. FCBP must also refrain from donating blood and/or egg while participating in the study and for at least 28 days after discontinuation from this study
  • FCBP must have two negative pregnancy tests (sensitivity of at least 25 mIU/mL) prior to starting study drug. The first pregnancy test must be performed within 10-14 days prior to the start of study drug and the second pregnancy test must be performed within 24 hours prior to the start of study drug.
  • Must agree to abstain from breastfeeding during study participation and for at least 28 days after study drug discontinuation.
  • Male Subjects must agree to complete abstinence or to use a condom during sexual contact with with a pregnant female or a female of childbearing potential while participating in the study and for at least 90 days following study drug discontinuation even if he has undergone a successful vasectomy
  • Must agree to counseling about sexual contact and the potential risks of fetal exposure to pomalidomide every 28 days.
  • Male subjects will be warned that sharing study drug is prohibited
  • Must agree to abstain from donating blood for at least 28 days following discontinuation of the study drug.
  • Must agree to abstain from donating semen or sperm during study participation and for at least 90 days after study drug discontinuation.
  • Must agree that if a pregnancy or a positive pregnancy test does occur in a the partner of a male study subject during study participation, the investigator must be notified immediately
  • Patients must agree to not share study drug with anyone during participation in the study.
  • Must understand and voluntarily sign an informed consent form, or must have a legally authorized representative who is able and willing to voluntarily sign an informed consent form on behalf of the patient.

Exclusion Criteria:

  • Pregnant or lactating females.
  • New immunosuppressive therapy started within the preceding 4 weeks.
  • Extracorporeal photopheresis within the preceding 3 months.
  • Hypersensitivity to any immune modulator drug (IMiD™).
  • Unable to take prophylactic anticoagulation.
  • Irreversible organ/tissue damage as the only manifestation or major determinant of overall severity of chronic GvHD (e.g., bronchiolitis obliterans).
  • Any condition which places the patient at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study.
  • Acute, persistent, recurrent or late-onset acute GvHD defined by NIH criteria.
  • Any of the following laboratory values at registration:

    • absolute neutrophil count (ANC) less than 1.0 x 109/L,
    • platelets less than 75 x 109/L, or
    • creatinine clearance less than 50 mL/min (Cockroft-Gault formula).
  • Uncontrolled infection requiring systemic antibiotics.
  • Known human immunodeficiency virus (HIV), hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection.
  • Known uncontrolled arrhythmias or symptomatic heart disease or left ventricular ejection fraction less than 40% (an ECHO should be performed as clinically indicated)
  • Recurrence of cancer for which the transplant was done except for presence of minimal residual disease by PCR.
  • Other cancer less than or equal to 2 years prior study-entry except:
  • Basal cell carcinoma of the skin,
  • Squamous cell carcinoma of the skin,
  • Carcinoma in situ of the cervix,
  • Carcinoma in situ of the breast, or
  • Prostate cancer (Tumor, Node, Metastasis [TNM] stage T1a or T1b)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00770757

Locations
United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63122
Sponsors and Collaborators
Washington University School of Medicine
Investigators
Principal Investigator: John F. DiPersio, M.D., Ph.D. Washington Univerisity School of Medicine
  More Information

Additional Information:
No publications provided

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT00770757     History of Changes
Other Study ID Numbers: 08-1093 / 201106102
Study First Received: October 7, 2008
Last Updated: August 9, 2013
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Graft vs Host Disease
Immune System Diseases
Pomalidomide
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors
Antineoplastic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on August 28, 2014