• Hopkins Verbal Learning Test Recall T-score [ Designated as safety issue: No ]
  
• WAIS-III Digit Span Subtest Scaled Score [ Designated as safety issue: No ]
  
• WAIS-III Symbol Search Subtest Scaled Score [ Designated as safety issue: No ]
  
• Ruff 2 and 7 Selective Attention Test Total Accuracy T-score [ Designated as safety issue: No ]
  
• Trailmaking Test Part B Speed Z-score [ Designated as safety issue: No ]
  
• Grooved Pegboard Test Dominant Hand Z-score [ Designated as safety issue: No ]
  

• Hopkins Verbal Learning Test Delayed Recall T-score [ Designated as safety issue: No ]
  
• Ruff 2 and 7 Selective Attention Test Total Speed T-score [ Designated as safety issue: No ]
  
• Trailmaking Test Part A Speed Z-score [ Designated as safety issue: No ]
  
• Grooved Pegboard Test Non-dominant Hand Z-score [ Designated as safety issue: No ]
  
• COWA Total Score [ Designated as safety issue: No ]
  
• NART-35 Total Score [ Designated as safety issue: No ]
  
• Barthel Index Total Score [ Designated as safety issue: No ]
  
• FACT-Br Domain and Total Scores [ Designated as safety issue: No ]
  

OBJECTIVES:

Primary

• To identify neuropsychological test scores that detect significant change in neuropsychological functioning in patients undergoing radiotherapy for brain metastases.
• To examine the relationship between neuropsychological function and survival of these patients.

Secondary

• To further examine whether other measures from the following battery of tests detect significant change in neuropsychological function or predict prognosis in these patients: North American Adult Reading Test-Short Form (NART-35), Hopkins Verbal Learning Test (HVLT), WAIS-III Digit Span Subtest, WAIS-III Symbol Search Subtest, Ruff 2 and 7 Selective Attention Test, Trail Making Test Part A and B (TMT), Controlled Oral Word Association Test (COWAT), Grooved Pegboard, Barthel Index, and the Functional Assessment of Cancer Therapy-Brain (FACT-Br).
• To examine the relationship between the RTOG recursive partitioning analysis (RPA) classification for brain metastasis survival and baseline neuropsychological functioning in these patients.
• To examine the strengths and weaknesses in neuropsychological functioning of these patients after radiotherapy.
• To explore the neuropsychological functioning of patients treated with different therapies (e.g., chemotherapy, corticosteroids, or complete surgical resection).
• To investigate the relationship between neuropsychological functioning, brain lesions (e.g., number and volume), MRI abnormalities, biomarkers, and disease progression or recurrence in these patients.
• To investigate the role of biomarkers, including NSE, S100B, MMPs, and VEGF, as potential markers of brain injury and disease progression using serum, plasma, and urine samples from these patients.
• To gather baseline neuropsychological data for use as a reference in the development of new clinical trials involving this patient population in the Radiation Oncology Branch (ROB).

OUTLINE: Patients are stratified according to RTOG recursive partitioning analysis (RPA) classification.

Patients undergo whole brain radiotherapy once daily 5 days a week for 2 weeks (10 fractions). Some patients may then undergo stereotactic radiosurgery boost.

Patients undergo neuropsychological testing (involving 40 minutes of direct cognitive testing and 15 minutes of questionnaires) at baseline and at 1, 3, 6, 9, and 12 months.

Blood and urine samples are collected periodically for laboratory biomarker studies. Blood samples are analyzed for NSE and S100B by ELISA. Urine samples are analyzed for MMP by ELISA.