Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.
| Condition | Intervention |
|---|---|
|
Aortic Valve Stenosis Coronary Disease |
Other: DSCT, TTE |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Diagnostic |
| Official Title: | Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography |
- Quality of cardiac imaging in computed tomography [ Time Frame: After comparison of imaging measurements ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 65 |
| Study Start Date: | May 2007 |
| Estimated Primary Completion Date: | December 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: AVS, CAD
DSCT
|
Other: DSCT, TTE
One assessment each
|
Detailed Description:
Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.
The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.
Eligibility| Ages Eligible for Study: | 40 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with aortic valve disease who were scheduled to undergo cardiac surgery
Exclusion Criteria:
- Hemodynamic instability
- Renal insufficiency (serum creatinine level > 133umol/L)
- Known allergy to iodinated contrast agents
- Non-treated hyperthyreosis
Contacts and Locations| Switzerland | |
| Luzerner Kantonsspital, Department of Cardiology | Recruiting |
| Lucerne, Luzern, Switzerland, 6000 | |
| Contact: Paul Erne, MD ++41 41 205 51 06 paul.erne@ksl.ch | |
| Contact: Christoph Auf der Maur, MD ++41 41 2005 51 48 | |
| Principal Investigator: Paul Erne, MD | |
| Sub-Investigator: Christoph Auf der Maur, MD | |
| Principal Investigator: | Paul Erne, MD | Luzerner Kantonsspital |
More Information
No publications provided
| Responsible Party: | Prof. Paul Erne, Luzerner Kantonsspital |
| ClinicalTrials.gov Identifier: | NCT00767013 History of Changes |
| Other Study ID Numbers: | Cardiac imaging DSCT |
| Study First Received: | October 3, 2008 |
| Last Updated: | April 16, 2013 |
| Health Authority: | Switzerland: Ethikkommission |
Keywords provided by Luzerner Kantonsspital:
|
DSCT, coronary artery disease, aortic valve stenosis |
Additional relevant MeSH terms:
|
Aortic Valve Stenosis Constriction, Pathologic Coronary Artery Disease Myocardial Ischemia Coronary Disease Heart Valve Diseases Heart Diseases |
Cardiovascular Diseases Ventricular Outflow Obstruction Pathological Conditions, Anatomical Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases |
ClinicalTrials.gov processed this record on May 19, 2013