Norepinephrine Weaning in Septic Patients (CATECHOFLOU)
The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.
Device: norepinephrine infused at the clinician's discretion
Device: norepinephrine infused under computerized fuzzy logic control
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Continuous Administration of Norepinephrine Assisted by Fuzzy Logic Assisted Control in Septic Shock Patients|
- Time to shock resolution defined as cessation of vasopressor support [ Designated as safety issue: Yes ]
- 28 days survival, total amount of norepinephrine infused, duration of mechanical ventilation, and length of stay in the ICU [ Designated as safety issue: Yes ]
|Study Start Date:||November 2004|
|Study Completion Date:||January 2007|
|Primary Completion Date:||November 2006 (Final data collection date for primary outcome measure)|
Placebo Comparator: 1
Patients were assigned to norepinephrine infused at the clinician's discretion.
|Device: norepinephrine infused at the clinician's discretion|
Active Comparator: 2
Patients were assigned to norepinephrine infused under computerized fuzzy logic control.
|Device: norepinephrine infused under computerized fuzzy logic control|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00763906
|Bobigny, Seine-Saint-Denis, France, 93000|