Periodontal Disease and Cardiovascular Disease

This study is ongoing, but not recruiting participants.

First Received: September 26, 2008 Last Updated: September 30, 2008 History of Changes

Sponsored by:	Colgate Palmolive
Information provided by:	Colgate Palmolive
ClinicalTrials.gov Identifier:	NCT00763165

Purpose

To access the influence of triclosan dentifrice on the progression of periodontal disease in patients with coronary heart disease.

Condition	Intervention	Phase
Periodontal Diseases	Drug: Triclosan Drug: Fluoride	Phase III

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Efficacy Study
Official Title:	Periodontal Disease and Cardiovascular Disease

Resource links provided by NLM:

Drug Information available for: Fluoride Triclosan Sodium fluoride Stannous fluoride

Further study details as provided by Colgate Palmolive:

Primary Outcome Measures:

Periodontal disease [ Time Frame: 3-5 Years ] [ Designated as safety issue: No ]

Enrollment:	438
Study Start Date:	November 2000
Estimated Study Completion Date:	December 2009
Estimated Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
A: Active Comparator	Drug: Triclosan Brush twice daily Drug: Fluoride Brush twice daily
B: Placebo Comparator	Drug: Fluoride Brush twice daily

Eligibility

Criteria

Inclusion Criteria:

Exclusion Criteria:

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00763165

Locations

Sponsors and Collaborators

Colgate Palmolive

Investigators

Principal Investigator:

Gregory Seymour, BDS

Unaffiliated

More Information

No publications provided

Responsible Party:	Colgate Palmolive ( William DeVizio/VP - Clinical Research )
Study ID Numbers:	D/06/Dent/99
Study First Received:	September 26, 2008
Last Updated:	September 30, 2008
ClinicalTrials.gov Identifier:	NCT00763165 History of Changes
Health Authority:	United States: Food and Drug Administration

Study placed in the following topic categories:

Mouth Diseases
Periodontal Diseases
Hexachlorophene

Stomatognathic Diseases
Fluorides
Triclosan

Additional relevant MeSH terms:

Mouth Diseases
Periodontal Diseases
Cariostatic Agents
Physiological Effects of Drugs
Cardiovascular Diseases

Stomatognathic Diseases
Fluorides
Protective Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on July 06, 2009