Effect of Stress on Heroin-Related Memory Retrieval

This study has been completed.
Sponsor:
Information provided by:
National Institute on Drug Dependence, China
ClinicalTrials.gov Identifier:
NCT00759005
First received: September 23, 2008
Last updated: NA
Last verified: September 2008
History: No changes posted
  Purpose

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.


Condition Intervention
Heroin Dependence
Learning and Memory
Drug: propranolol and cortisol

Study Type: Interventional

Resource links provided by NLM:


Further study details as provided by National Institute on Drug Dependence, China:

Primary Outcome Measures:
  • Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts [ Designated as safety issue: Yes ]

Study Start Date: March 2007
Study Completion Date: September 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A, 4 Drug: propranolol and cortisol

  Eligibility

Ages Eligible for Study:   20 Years to 40 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria:

  • current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00759005

Locations
China, Beijing
National Institute on Drug Dependence
Beijing, Beijing, China, 100191
Sponsors and Collaborators
National Institute on Drug Dependence, China
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00759005     History of Changes
Other Study ID Numbers: NIDD
Study First Received: September 23, 2008
Last Updated: September 23, 2008
Health Authority: China: Peking University Research Ethics Committee

Additional relevant MeSH terms:
Heroin Dependence
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders

ClinicalTrials.gov processed this record on October 01, 2014