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The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging (MARATHON-MRI)

This study has been completed.
Information provided by (Responsible Party):
Lihua QU, William Beaumont Hospitals Identifier:
First received: September 12, 2008
Last updated: April 2, 2012
Last verified: April 2012

Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon. In addition, the investigators aim to describe the acute and chronic structural abnormalities that occur as a result of endurance training. The study hypothesis is that myocardial necrosis is present in runners completing a marathon competition.

Myocardial Ischemia
Left Ventricular Systolic Dysfunction
Elevated Cardiac Enzymes

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging

Resource links provided by NLM:

Further study details as provided by William Beaumont Hospitals:

Biospecimen Retention:   Samples Without DNA


Enrollment: 25
Study Start Date: September 2008
Study Completion Date: May 2010
Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
Detailed Description:

MARATHON-MI is a prospective, observational study of twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008. All participants will undergo a rigorous pre-marathon screening process which will include: 1) blood testing, 2) complete cardiopulmonary exercise testing, 3) ECG testing, 4) Holter monitoring, 5) cardiac MRI. Blood work will be check after the marathon immediately after and one day after the event. Cardiac MRI will be repeated within 12 hours of finishing the marathon. Using the information derived from the blood work and radiological testing, we will attempt to determine if there is an association between marathon running and myocardial necrosis.


Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008.


Inclusion Criteria:

  • Detroit Free Press Marathon participant on October 19, 2008,
  • Age > 18 years old,
  • Ability to provide informed consent.

Exclusion Criteria:

  • Known coronary or structural heart disease
  • Pregnancy,
  • Extreme claustrophobia,
  • Metal implants,
  • Renal dysfunction.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00752752

United States, Michigan
William Beaumont Hospital
Royal Oak, Michigan, United States, 48009
Sponsors and Collaborators
William Beaumont Hospitals
Principal Investigator: Justin E Trivax, MD Physician
  More Information

No publications provided

Responsible Party: Lihua QU, Coordinator, William Beaumont Hospitals Identifier: NCT00752752     History of Changes
Other Study ID Numbers: HIC2008-083
Study First Received: September 12, 2008
Last Updated: April 2, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by William Beaumont Hospitals:
Marathon Running
Cardiac Ischemia
Magnetic Resonance Imaging

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Ventricular Dysfunction, Left
Arterial Occlusive Diseases
Cardiovascular Diseases
Coronary Disease
Heart Diseases
Pathologic Processes
Vascular Diseases
Ventricular Dysfunction processed this record on November 25, 2014