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Diagnosis of Exercise-Induced Bronchospasm (EIB) and Asthma in National Collegiate Athletic Association (NCAA) Division I Athletes
This study is currently recruiting participants.
Verified by University of Arizona, September 2008
First Received: September 11, 2008   Last Updated: September 12, 2008   History of Changes
Sponsor: University of Arizona
Collaborator: GlaxoSmithKline
Information provided by: University of Arizona
ClinicalTrials.gov Identifier: NCT00752167
  Purpose

We hypothesize that exercise-induced bronchospasm (EIB) at the NCAA Division I collegiate level is over diagnosed, while poorly controlled asthma resulting in exercise-related symptoms in this same population may be under diagnosed, being erroneously attributed to EIB. This project will test individuals self-identified as having exercise induced bronchospasm or asthma, as well as gender-matched controls from the same sport, with eucapnic voluntary hyperventilation to assess for the presence of EIB or asthma. By making the correct diagnosis, improved health outcomes may be achieved and athletic performance may be enhanced.


Condition
Exercise Induced Bronchospasm, Asthma

Study Type: Observational
Study Design: Case Control, Cross-Sectional
Official Title: Diagnosis of EIB and Asthma in NCAA Division I Athletes

Resource links provided by NLM:


Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Change in FEV1 following eucapnic voluntary hyperventilation [ Time Frame: 3-21 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Protection from fall in FEV1 following eucapnic voluntary hyperventilation by preadministration of albuterol [ Time Frame: 3-21 minutes ] [ Designated as safety issue: No ]

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment: 75
Study Start Date: February 2007
Groups/Cohorts
Case
all Division I athletes, male and female, at the University of Arizona that are currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff
Control
control athletes (ie, not currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff and/or not currently using asthma medications) from the same sport

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

NCAA Varsity Division I athletes attending the University of Arizona

Criteria

Inclusion Criteria:

  • varsity athlete
  • ability and willingness to give written informed consent

Exclusion Criteria:

  • inability to give written informed consent
  • unwillingness to perform spirometry or eucapnic voluntary hyperventilation
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00752167

Contacts
Contact: David Millward, MD 520-626-6363 millward@msu.edu
Contact: Mark A Brown, MD 520-626-7780 mabrown@arc.arizona.edu

Locations
United States, Arizona
University of Arizona Recruiting
Tucson, Arizona, United States, 85724
Contact: David Millward, MD     520-626-6363     millward@msu.edu    
Sub-Investigator: Mark A Brown, MD            
Principal Investigator: David Millward, MD            
Sub-Investigator: Stephen Paul, MD            
Sub-Investigator: Donald Porter, MD            
Sub-Investigator: Michael Stilson, MD            
Sponsors and Collaborators
University of Arizona
GlaxoSmithKline
  More Information

No publications provided

Responsible Party: University of Arizona ( David Millward, MD )
Study ID Numbers: GSK 110189
Study First Received: September 11, 2008
Last Updated: September 12, 2008
ClinicalTrials.gov Identifier: NCT00752167     History of Changes
Health Authority: United States: Institutional Review Board

Keywords provided by University of Arizona:
exercise induced bronchospasm
asthma
athlete
sports
eucapnic voluntary hyperventilation
albuterol

Additional relevant MeSH terms:
Asthma, Exercise-Induced
Hypersensitivity
Lung Diseases, Obstructive
Bronchial Spasm
Immune System Diseases
Respiratory Tract Diseases
Bronchial Diseases
Lung Diseases
Hypersensitivity, Immediate
Asthma
Respiratory Hypersensitivity

ClinicalTrials.gov processed this record on November 05, 2009