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Urine Concentration of S100B in Extremely Premature Infants

This study has been completed.
Sponsor:
Information provided by:
University of Utah
ClinicalTrials.gov Identifier:
NCT00747591
First received: September 3, 2008
Last updated: July 21, 2010
Last verified: July 2010
History of Changes
  Purpose

S100B, a calcium-binding protein, is found predominantly in the central nervous system (CNS) and is increased in CSF and blood after CNS injury. There are two objectives to this study. Is urine S100B concentration correlated with the serum concentration of S100B in infants born at 29-36 weeks gestation. The presence and severity of intracranial pathology on S100B concentration will be investigated. Further analysis will demonstrate if birth weight, daily fluid intake, urine output, and urine creatinine influence this relationship.


Condition
Premature Infants

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Correlation of Urine Concentration of S100B in Extremely Premature Infants With Gestational Age and Severity of Intraventricular Hemorrhage

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Utah:

Enrollment: 68
Study Start Date: November 2002
Study Completion Date: April 2005
Primary Completion Date: February 2005 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   up to 7 Days
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Preterm infants born at <28 weeks gestation will be eligible for enrollment in this study.

Criteria

Inclusion Criteria:

  • Preterm infants born at <28 weeks gestation will be eligible for enrollment in this study.

Exclusion Criteria:

  • Infants with fetal malformations, chromosomal anomalies, and clinically significant sepsis (retractable hypotension, neutropenia, and thrombocytopenia) will be excluded, other.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00747591

Locations
United States, Utah
University of Utah
Salt Lake City, Utah, United States, 84132
Sponsors and Collaborators
University of Utah
Investigators
Principal Investigator: Joanna Beachy, M.D. University of Utah
  More Information

No publications provided

Responsible Party: Joanna Beachy Ph.D., M.D., University of Utah Neonatology
ClinicalTrials.gov Identifier: NCT00747591     History of Changes
Other Study ID Numbers: 10870
Study First Received: September 3, 2008
Last Updated: July 21, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by University of Utah:
urine
concentration
of S100B

ClinicalTrials.gov processed this record on May 23, 2013