Acute Effects of Smoking on Airway Dendritic Cells
Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Acute Effects of Smoking on Airway Dendritic Cells|
- Total number of dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]
- Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]
|Study Start Date:||June 2008|
|Study Completion Date:||December 2008|
|Primary Completion Date:||November 2008 (Final data collection date for primary outcome measure)|
Active Comparator: 1
Participants smoke 8 cigarettes in 4 hours.
Active Comparator: Participants smoke 8 cigarettes in 4 hours.
Sham Comparator: 2
Participants are not allowed to smoke for 4 hours.
Sham Comparator: Participants are not allowed to smoke for 4 hours.
|University of Rostock|
|Rostock, Germany, 18057|
|Study Chair:||Johann C. Virchow, Professor, MD, FRCP, FCCP||University of Rostock|