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Acute Effects of Smoking on Airway Dendritic Cells

This study has been completed.
Sponsor:
Collaborator:
German Research Foundation
Information provided by:
University of Rostock
ClinicalTrials.gov Identifier:
NCT00740896
First received: August 22, 2008
Last updated: April 7, 2009
Last verified: April 2009
History of Changes
  Purpose

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.


Condition Intervention
Tobacco Use Disorder
 Behavioral: Smoking

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Acute Effects of Smoking on Airway Dendritic Cells

Resource links provided by NLM:

MedlinePlus related topics: Smoking
U.S. FDA Resources

Further study details as provided by University of Rostock:

Primary Outcome Measures:
  • Total number of dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]

Enrollment: 16
Study Start Date: June 2008
Study Completion Date: December 2008
Primary Completion Date: November 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Participants smoke 8 cigarettes in 4 hours.
 Behavioral: Smoking
Active Comparator: Participants smoke 8 cigarettes in 4 hours.
Sham Comparator: 2
Participants are not allowed to smoke for 4 hours.
 Behavioral: Smoking
Sham Comparator: Participants are not allowed to smoke for 4 hours.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Active smoking (at least 10 cigarettes per day)
  • Age > 18 years

Exclusion Criteria:

  • Any chronic diseases
  • Any regular medication
  • Any signs or symptoms of an acute infection
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00740896

Locations
Germany
University of Rostock
Rostock, Germany, 18057
Sponsors and Collaborators
University of Rostock
German Research Foundation
Investigators
Study Chair: Johann C. Virchow, Professor, MD, FRCP, FCCP University of Rostock
  More Information

Publications:

Responsible Party: PD Dr. med. Marek Lommatzsch, University of Rostock
ClinicalTrials.gov Identifier: NCT00740896     History of Changes
Other Study ID Numbers: LO-2222
Study First Received: August 22, 2008
Last Updated: April 7, 2009
Health Authority: Germany: Ethics Commission

Keywords provided by University of Rostock:
Cigarette Smoking
Airway dendritic cells

Additional relevant MeSH terms:
Smoking
Tobacco Use Disorder
Habits
Substance-Related Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 19, 2013