Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by Johns Hopkins University
Sponsor:
Collaborators:
Information provided by (Responsible Party):
John E. Desmond, Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT00740701
First received: August 22, 2008
Last updated: March 26, 2014
Last verified: March 2014
  Purpose

Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.


Condition Intervention
Cognitive Performance
Device: Cerebellar transcranial magnetic stimulation

Study Type: Interventional
Study Design: Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: fMRI and TMS Analysis of Cerebellar Cognitive Function

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • Behavioral performance (accuracy, or rate of conditioned responses) [ Time Frame: during computerized task performance (2 hours) ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Reaction time [ Time Frame: during performance of computerized task (2 hours) ] [ Designated as safety issue: No ]

Estimated Enrollment: 188
Study Start Date: April 2000
Estimated Study Completion Date: July 2015
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: Cerebellar transcranial magnetic stimulation
    single pulse TMS or repetitive TMS at 1 Hz frequency
  Eligibility

Ages Eligible for Study:   19 Years to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 19-30 years of age
  • Informed consent

Exclusion Criteria:

  • History of seizure or a family history of epilepsy
  • History of stroke
  • Presence of metal anywhere in the head except the mouth
  • Presence of cardiac pacemakers
  • Presence of cochlear implants
  • Presence of implanted medication pump
  • History of heart disease
  • Presence of intracardiac lines
  • Increased intracranial pressure, such as after infarctions or trauma
  • Children, or outside of age range
  • Pregnancy
  • Currently taking tricyclic anti-depressants or neuroleptic medication
  • History of head trauma
  • History of respiratory disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00740701

Contacts
Contact: Jessica Rilee, B.S. 410-502-5151 jrilee1@jhmi.edu
Contact: John E Desmond, Ph.D. 410-502-3583 dr.jdesmond@gmail.com

Locations
United States, Maryland
Kennedy Krieger Institute Recruiting
Baltimore, Maryland, United States, 21205
Principal Investigator: John E Desmond, Ph.D.         
Sub-Investigator: Cherie Marvel, Ph.D         
Sub-Investigator: Dominic Cheng, Ph.D.         
Sub-Investigator: Sara H Ying, M.D.         
Sponsors and Collaborators
John E. Desmond
Investigators
Principal Investigator: John E Desmond, Ph.D. Johns Hopkins University
  More Information

No publications provided

Responsible Party: John E. Desmond, Professor of Neurology, Johns Hopkins University
ClinicalTrials.gov Identifier: NCT00740701     History of Changes
Other Study ID Numbers: G000078, R01 MH060234, R01 AG021501
Study First Received: August 22, 2008
Last Updated: March 26, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Johns Hopkins University:
TMS
fMRI
verbal working memory
classical conditioning
eyeblink
classical eyeblink conditioning
Healthy subjects
Memory

ClinicalTrials.gov processed this record on September 29, 2014