Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

The recruitment status of this study is unknown because the information has not been verified recently.

Verified January 2010 by Johns Hopkins University.
Recruitment status was Recruiting

Sponsor:

Collaborators:

National Institute of Mental Health (NIMH)

National Institute on Aging (NIA)

Information provided by:

Johns Hopkins University

ClinicalTrials.gov Identifier:

NCT00740701

First received: August 22, 2008

Last updated: June 30, 2011

Last verified: January 2010

History of Changes

Purpose

Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Condition	Intervention
Cognitive Performance	Device: Cerebellar transcranial magnetic stimulation

Study Type:	Interventional
Study Design:	Intervention Model: Crossover Assignment Masking: Single Blind (Subject) Primary Purpose: Basic Science
Official Title:	fMRI and TMS Analysis of Cerebellar Cognitive Function

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:

Behavioral performance (accuracy, or rate of conditioned responses) [ Time Frame: during computerized task performance (2 hours) ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Reaction time [ Time Frame: during performance of computerized task (2 hours) ] [ Designated as safety issue: No ]

Estimated Enrollment:	188
Study Start Date:	April 2000
Estimated Primary Completion Date:	July 2012 (Final data collection date for primary outcome measure)

Intervention Details:

single pulse TMS or repetitive TMS at 1 Hz frequency

Eligibility

Ages Eligible for Study:	19 Years to 30 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

19-30 years of age
Informed consent

Exclusion Criteria:

History of seizure or a family history of epilepsy
History of stroke
Presence of metal anywhere in the head except the mouth
Presence of cardiac pacemakers
Presence of cochlear implants
Presence of implanted medication pump
History of heart disease
Presence of intracardiac lines
Increased intracranial pressure, such as after infarctions or trauma
Children, or outside of age range
Pregnancy
Currently taking tricyclic anti-depressants or neuroleptic medication
History of head trauma
History of respiratory disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00740701

Contacts

Contact: Monica L Faulkner	410-502-5151	mfaulkn4@jhmi.edu
Contact: John E Desmond, Ph.D.	410-502-3583	dr.jdesmond@gmail.com

Locations

United States, Maryland
Kennedy Krieger Institute	Recruiting
Baltimore, Maryland, United States, 21205
Principal Investigator: John E Desmond, Ph.D.
Sub-Investigator: Cherie Marvel, Ph.D
Sub-Investigator: Dominic Cheng, Ph.D.
Sub-Investigator: Sara H Ying, M.D.

Sponsors and Collaborators

Johns Hopkins University

National Institute of Mental Health (NIMH)

National Institute on Aging (NIA)

Investigators

Principal Investigator:

John E Desmond, Ph.D.

Johns Hopkins University

More Information

No publications provided

Responsible Party:	John E. Desmond, Ph.D., Associate Professor, Johns Hopkins University, Department of Neurology
ClinicalTrials.gov Identifier:	NCT00740701 History of Changes
Other Study ID Numbers:	G000078, R01 MH060234, R01 AG021501
Study First Received:	August 22, 2008
Last Updated:	June 30, 2011
Health Authority:	United States: Food and Drug Administration

Keywords provided by Johns Hopkins University:

TMS
fMRI
verbal working memory
classical conditioning

eyeblink
classical eyeblink conditioning
Healthy subjects
Memory

ClinicalTrials.gov processed this record on June 18, 2013

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