Rituximab, Bortezomib, Doxorubicin, Dexamethasone, and Chlorambucil as First-Line Therapy in Treating Older Patients With Stage II, Stage III, or Stage IV Mantle Cell Lymphoma
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Purpose
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin, dexamethasone, and chlorambucil, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy together with rituximab and bortezomib may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving rituximab together with bortezomib, doxorubicin, dexamethasone, and chlorambucil works as first-line therapy in treating older patients with stage II, stage III, or stage IV mantle cell lymphoma.
| Condition | Intervention | Phase |
|---|---|---|
|
Lymphoma |
Biological: rituximab Drug: bortezomib Drug: chlorambucil Drug: dexamethasone Drug: doxorubicin hydrochloride |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Masking: Open Label Primary Purpose: Treatment |
| Official Title: | First-line Treatment of Mantle Cell Lymphoma of Patients Aged 65 to 80 Years. Evaluate the Efficacy, Toxicity, and Molecular Prognostic Factors of a Proteosome Inhibitor (PS341-Velcade®) in Association With Chemotherapy and Immunotherapy With Rituximab (Schema RiPAD + C) |
- Overall response rate after 4 courses of therapy [ Designated as safety issue: No ]
| Estimated Enrollment: | 39 |
| Study Start Date: | June 2007 |
| Primary Completion Date: | May 2011 (Final data collection date for primary outcome measure) |
OBJECTIVES:
Primary
- Evaluate the efficacy of rituximab, bortezomib, doxorubicin hydrochloride, dexamethasone, and chlorambucil as first-line therapy in patients with stage II-IV mantle cell lymphoma.
Secondary
- Determine the complete response rate in these patients.
- Determine the efficacy, in terms of complete and overall response, by F18 fludeoxyglucose scan.
- Determine overall, disease-free, and event-free survival of these patients.
- Assess tolerability of this regimen in these patients.
- Evaluate the impact of factors, described in previous protocols, on response to therapy and survival.
- Assess the impact of residual disease in cerebrospinal fluid on survival.
OUTLINE: This is a multicenter study.
Patients receive rituximab IV on day 1 (days 1 and 8 of the first course only); bortezomib IV on days 1, 4, 8, and 11; doxorubicin hydrochloride IV continuously over 24 hours on days 1-4; dexamethasone IV on days 1-4; and oral chlorambucil on days 20-29. Treatment repeats every 5 weeks for 4 courses in the absence of disease progression or unacceptable toxicity.
Patients who achieve at least 50% response receive 2 additional courses of therapy.
Eligibility| Ages Eligible for Study: | 65 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Diagnosis of mantle cell lymphoma
- Stage II-IV disease
- No neuromeningeal disease
PATIENT CHARACTERISTICS:
- WHO performance status 0-2
- No prior cancer except for carcinoma in situ of the cervix or basal cell skin cancer
- LVEF > 50%
- HIV-negative
- Hepatitis B- and C-negative
- No hepatocellular, renal, or bone marrow insufficiency unrelated to lymphoma
PRIOR CONCURRENT THERAPY:
- Not specified
Contacts and Locations| France | |
| CHU de Grenoble - Hopital Michallon | |
| Grenoble, France, 38043 | |
| Study Chair: | Remy Gressin, MD | CHU de Grenoble - Hopital de la Tronche |
More Information
Additional Information:
No publications provided
| ClinicalTrials.gov Identifier: | NCT00740415 History of Changes |
| Other Study ID Numbers: | CDR0000589544, GOELAMS-MANTEAU-2006-SA, INCA-RECF0475 |
| Study First Received: | August 22, 2008 |
| Last Updated: | May 10, 2011 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
|
contiguous stage II mantle cell lymphoma noncontiguous stage II mantle cell lymphoma stage III mantle cell lymphoma stage IV mantle cell lymphoma |
Additional relevant MeSH terms:
|
Lymphoma Lymphoma, Mantle-Cell Neoplasms by Histologic Type Neoplasms Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Lymphoma, Non-Hodgkin Chlorambucil Rituximab Bortezomib Dexamethasone Doxorubicin Dexamethasone acetate |
Dexamethasone 21-phosphate BB 1101 Antineoplastic Agents, Alkylating Alkylating Agents Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Antineoplastic Agents Therapeutic Uses Anti-Inflammatory Agents Antiemetics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Central Nervous System Agents Gastrointestinal Agents |
ClinicalTrials.gov processed this record on May 23, 2013