Dietary Phytosterols and Human Aortic Valve
Recruitment status was Recruiting
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Purpose
This randomized controlled double-blind intervention study unravels influence of dietary plant sterols and stanols on the structure and the sterol composition of the human aortic valve. The study patients will include 50-60 voluntary patients from the Helsinki Univ. Central Hospital, who will undergo aortic valve surgery. The patients will be randomized into plant sterol (E), plant stanol (A) and control (C) groups. Patients in the E and A groups will be asked to consume daily 2 grams plant sterols or plant stanols, respectively, in a margarine product.
| Condition | Intervention |
|---|---|
|
Hypercholesterolemia Atherosclerosis |
Dietary Supplement: Dietary plant stanols Dietary Supplement: Dietary plant sterols Dietary Supplement: placebo |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Factorial Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment |
| Official Title: | Effects of Dietary Plant Sterols and Stanols on Sterol Composition and Structure of the Human Aortic Valve |
- Composition of serum and aortic valve sterols at the time of aortic valve operation [ Time Frame: Up to 4 weeks ] [ Designated as safety issue: Yes ]
| Estimated Enrollment: | 60 |
| Study Start Date: | April 2008 |
| Estimated Study Completion Date: | December 2011 |
| Estimated Primary Completion Date: | December 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: A
A group of patients consuming 2 grams plant stanols 4-8 weeks before the operation
|
Dietary Supplement: Dietary plant stanols
Daily 2 grams of plant stanols in a margarine preparation for 4-8 weeks before the operation
|
|
Active Comparator: E
A group of patients consuming daily 2 grams plant sterols 4-8 weeks before the operation.
|
Dietary Supplement: Dietary plant sterols
Daily 2 grams of plant sterols in a margarine preparation for 4-8 weeks before the operation
|
| Placebo Comparator: C |
Dietary Supplement: placebo
Margarine product without plant stanol or sterol esters
|
Detailed Description:
High level of serum cholesterol is a risk factor for atherosclerotic complications, including atherosclerotic aortic valve disease. Over 50 years dietary plant sterols have been used to inhibit intestinal cholesterol absorption and to decrease its levels in serum. Daily human diet contains numerous different plant sterols, of which sitosterol and campesterol are the most abundant ones. Few epidemiologic studies suggest that sitosterol and campesterol may also be involved in formation of atherosclerotic changes in human arteries. The saturated forms of sitosterol and campesterol, i.e., the plant stanols (mainly sitostanol and campestanol) are beneficial with this respect. As part of daily diet, the plant stanols decrease absorption of both cholesterol and plant sterols, and thus, are putatively even more effective in prevention of atherosclerosis than the respective plant sterols.
Our double-blind controlled intervention study unravels influence of dietary plant sterols and stanols on the structure and the sterol composition of the human aortic valve.
50-60 patients, who will undergo aortic valve surgery, will be asked to volunteer our study. The patients will be randomized into three groups: (A) a group consuming margarine containing daily 2 grams plant stanols, (E) a group consuming margarine containing daily 2 grams of plant sterols, (C) a control group consuming margarine without any plant sterols or stanols. The dietary intervention will last for 4 to 8 weeks from the randomization to the operation.
Serum samples for analyses of serum lipids, lipoproteins and sterols will be collected at the randomization and at the operation. The atherosclerotic aortic valve will be examined with respect to its composition of cholesterol, other sterols and stanols.
The aim of our study is to elucidate the effects of dietary consumption of plant sterols and stanols on the sterol composition and structure of the atherosclerotic disease-affected aortic valve in human patients.
Eligibility| Ages Eligible for Study: | 40 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Atherosclerotic aortic valve disease needing an aortic valve replacement operation
Exclusion Criteria:
- None
Contacts and Locations| Contact: Markku J. Nissinen, MD, PhD | +358 9 4711 | markku.nissinen@hus.fi |
| Finland | |
| Department of Medicine, Div. of Internal Medicine, Helsinki Univ. Central Hospital (HUCH) | Recruiting |
| Helsinki, Finland, 00029HUS | |
| Contact: Markku Nissinen, MD, PhD +358 9 4711 markku.nissinen@hus.fi | |
| Principal Investigator: Tatu A Miettinen, Professor | |
| Sub-Investigator: Markku J Nissinen, MD, PhD | |
| Principal Investigator: | Tatu A. Miettinen, professor | Dept. of Medicine, Div. of Internal Medicine, Helsinki Univ. Central Hospital, Biomedicum Helsinki |
| Principal Investigator: | Helena Gylling, Professor | Department of Clinical Nutrition, University of Kuopio and Kuopion University Central Hospital, Kuopio, Finland |
| Principal Investigator: | Markku J Nissinen, MD, PhD | Dept. of Medicine, Div. of Gastroenterology, HUCH, Helsinki, Finland |
More Information
No publications provided
| Responsible Party: | Markku Nissinen, MD PhD, Helsinki University Central Hospital |
| ClinicalTrials.gov Identifier: | NCT00738933 History of Changes |
| Other Study ID Numbers: | 231857 |
| Study First Received: | August 20, 2008 |
| Last Updated: | February 11, 2011 |
| Health Authority: | Finland: Ethics Committee |
Keywords provided by Helsinki University:
|
Atherosclerosis Plant sterols Plant stanols Aortic valve |
Additional relevant MeSH terms:
|
Atherosclerosis Hypercholesterolemia Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases |
Cardiovascular Diseases Hyperlipidemias Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases |
ClinicalTrials.gov processed this record on May 19, 2013