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Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department

This study has been completed.
Sponsor:
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00738816
First received: August 20, 2008
Last updated: December 13, 2010
Last verified: December 2010
  Purpose

Elderly patients have a higher risk of experiencing adverse drug events due to an age related increase in morbidity and medication use. Inappropriate or wrong medication use among elderly patients acutely admitted to hospitals is assumed to result in earlier contact to general practitioner, emergency departments and re-admissions if not corrected during hospital admission. It is therefore our hypothesis that a systematic medication review conducted by pharmacists and physicians specialized in pharmacology will increase time to first unscheduled physician contact (general practitioner, emergency departments, ambulatory care and re-admissions) after discharge from hospital from an average of 21days to 25 days. Further, the following secondary outcome parameters will be measured at discharge and within 3-month follow-up:

  • length of in-hospital stay
  • number of contacts to general practitioner 30 days after discharge, that resulted in medication changes
  • number of re-admissions at 3-month
  • number of death at 3-month
  • number of contact to primary health care at 3-month
  • patients self-experienced quality of health(EQ-5D) 3-month

Condition Intervention
Elderly
Other: Systematic medication review and advisory notes

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department.

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Time to first unscheduled physician contact(general practitioner,emergency department, ambulatory care or re-admission to hospital) after discharge from the Orthopaedic Department [ Time Frame: January 2010 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Admission time [ Time Frame: October 2009 ] [ Designated as safety issue: No ]

Enrollment: 108
Study Start Date: April 2009
Study Completion Date: April 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Intervention
Systematic medication review
Other: Systematic medication review and advisory notes
Within 24 hours of admission a pharmacist retrieve medication histories from patients included in the intervention group. Medication histories will be obtained from - medical records, medication charts, patients electronical medication profile, interview with patients and if necessary contact to the patients general practitioner. The obtained medication history will be discussed with a physician specialized in pharmacology and an advisory note with suggested changes to the patients medication is added to the medical record. The orthopedic physicians are not obliged to follow the suggested changes

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • age 65 years or older
  • expected admission time of more than 24 hours
  • acute admission

Exclusion Criteria:

  • Psychotic patients
  • Moribund patients
  • Suicidal patients
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00738816

Locations
Denmark
Regional hospital, Randers
Randers, Central Denmark Region, Denmark, 8900
Sponsors and Collaborators
Aarhus University Hospital
Investigators
Principal Investigator: Nielsen Lars Peter, Assoc. Prof. Aarhus University Hospital, Denmark
  More Information

Publications:
Responsible Party: Marianne Lisby, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00738816     History of Changes
Other Study ID Numbers: Klinfarm
Study First Received: August 20, 2008
Last Updated: December 13, 2010
Health Authority: Denmark: Danish Dataprotection Agency
Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by University of Aarhus:
Medication review
Patient
Safety
Drug
Prescriptions
Drug-use

ClinicalTrials.gov processed this record on November 20, 2014