Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination
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Purpose
Endometrial sampling improves the pregnancy rates in superovulation-IUI cycles
| Condition | Intervention |
|---|---|
|
Infertility Clinical Pregnancy Rate |
Procedure: Endometrial sampling |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination |
- The rate of clinical pregnancy [ Time Frame: 24 months ] [ Designated as safety issue: Yes ]
| Enrollment: | 9 |
| Study Start Date: | August 2008 |
| Study Completion Date: | August 2011 |
| Primary Completion Date: | August 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
No Intervention: 1
Group 1 patients will receive standard superovulation-IUI treatment without endometrial sampling
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|
Active Comparator: 2
Group 2 patients will receive standard superovulation-IUI treatment with endometrial sampling performed in the preceding cycle. It will be done in the follicular phase not later than day 10 of the cycle
|
Procedure: Endometrial sampling
Endometrial sampling performed in the preceding cycle. It will be done in the follicular phase not later than day 10 of the cycle
Other Names:
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Detailed Description:
Endometrial sampling is performed using the standard technique in the outpatient department. Similarly, superovulation with gonadotrophins will be performed according to our standard practice.Endometrial sampling will be done in the follicular phase not later than day 10 of the cycle. Endometrial sampling will be performed using Pipelle sampling catheter. The Pipelle is inserted gently through the cervical canal into the uterine cavity and advanced slowly till just resistance felt by the operator. Then, the piston is withdrawn to create negative suction and gentle movement of Pipelle up and down in the uterine cavity is performed while it is against the uterine wall. The Pipelle catheter is withdrawn gently and any obtained specimen will be sent for histopathological examination.
Eligibility| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- All women undergoing superovulation with gonadotrophins and intrauterine insemination.
- All women with cervical factor, mild male factor and/or unexplained infertility.
- At least one patent Fallopian tube.
Exclusion Criteria:
- Bilateral tubal disease
- Severe male factor infertility
- Intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions)
- Women with positive cervical culture and/or acute vaginal infection
Contacts and Locations| Canada, Quebec | |
| McGill University Health Center | |
| Montreal, Quebec, Canada, H3A 1A1 | |
| Principal Investigator: | Togas Tulandi, MD, MHCM | McGill University Health Center |
More Information
Publications:
| Responsible Party: | Mohammed Agdi, Consultant Reproductive Endocrinology and Infertility, McGill University Health Center |
| ClinicalTrials.gov Identifier: | NCT00737984 History of Changes |
| Other Study ID Numbers: | SDR-08-004 |
| Study First Received: | August 18, 2008 |
| Last Updated: | April 19, 2012 |
| Health Authority: | Canada: Ethics Review Committee |
Keywords provided by McGill University Health Center:
|
Infertility Clinical pregnancy rate |
Additional relevant MeSH terms:
|
Infertility Adenoma Genital Diseases, Male Genital Diseases, Female |
Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms |
ClinicalTrials.gov processed this record on May 19, 2013