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Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2008 by Assaf-Harofeh Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Assaf-Harofeh Medical Center
ClinicalTrials.gov Identifier:
NCT00731159
First received: August 7, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted
  Purpose

Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments


Condition Intervention
Sperm Capacitation
Biological: sperm capacitation
Other: biologic
Other: sperm capacitation

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Resource links provided by NLM:


Further study details as provided by Assaf-Harofeh Medical Center:

Primary Outcome Measures:
  • Fertilization rate of human oocytes in thr "routine" IVF Laboratory work [ Time Frame: One year ] [ Designated as safety issue: No ]

Estimated Enrollment: 50
Study Start Date: July 2008
Estimated Study Completion Date: July 2009
Estimated Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
A

Sperm capacitation:

Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

Biological: sperm capacitation
sperm capacitation measured at Bar Ilan University
Other: biologic
sperm synthesis of G-actine to F-actine
Other Name: sperm capacitation
Other: sperm capacitation
sperm synthesis of G-actine to F-actine
Other Name: sperm synthesis of G-actine to F-actine

Detailed Description:

Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients requiring IVF within the "routine" work of an IVF Unit

Criteria

Inclusion Criteria:

  • Patients requiring IVF within the "routine" work of an IVF Unit
  • normo-responding woman
  • non ICSI cycles

Exclusion Criteria:

  • Patients undergoing ICSI only cycle
  • Low responders-less than 8 oocytes
  • Male patients with low semen volume
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00731159

Contacts
Contact: arieh raziel, prof 97289779005 araziel@asaf.health.gov.il
Contact: raphael ron-el, prof 97289779005 rronel@asaf.health.gov.il

Locations
Israel
Assaf Harofeh MC Recruiting
Beer Yaacov, Zerifin, Israel, 70300
Contact: arieh raziel, prof    97289779005    araziel@asaf.health.gov.il   
Contact: raphael ron-el, prof    97289779005    rronel@asaf.health.gov.il   
Principal Investigator: arieh raziel, prof         
Sub-Investigator: raphael ron-el, prof         
Sponsors and Collaborators
Assaf-Harofeh Medical Center
  More Information

No publications provided

Responsible Party: Prof A Raziel, Assaf Harofeh MC
ClinicalTrials.gov Identifier: NCT00731159     History of Changes
Other Study ID Numbers: 54/08
Study First Received: August 7, 2008
Last Updated: August 7, 2008
Health Authority: Israel: Assaf Harofeh "Helsinky" review board

ClinicalTrials.gov processed this record on November 20, 2014