Biomarker for Peritoneal Ultrafiltration Failure
Recruitment status was Recruiting
This study will examine the peritoneal tissue, serum and dialysate proteins of peritoneal dialysis (PD) patients with different types of peritoneal solute transport by differential proteomics techniques.
This study will be performed to identify the molecular difference between different types of peritoneal solute transport and explore biomarker for early detection as well as early intervention of peritoneal ultrafiltration failure.
Continuous Ambulatory Peritoneal Dialysis
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Biomarker for Early Detection and Intervention of Peritoneal Ultrafiltration Failure|
peritoneal tissue will be collected at the time of peritoneal dialysis catheter insertion or extubation. Serum and dialysate samples will be collected for protein analysis.
|Study Start Date:||October 2007|
|Estimated Study Completion Date:||July 2011|
|Estimated Primary Completion Date:||July 2009 (Final data collection date for primary outcome measure)|
Ultrafiltration failure (UFF) is an important cause of technical failure in PD patients. It may develop over time and is, therefore, especially important in longterm PD. However, the study on UFF is very limited so far, there are still lack of biomarker for early detection and intervention of UFF.
Proteomics uses a rapidly evolving group of technologies to identify, quantify, and characterize a global set of proteins. It is characterized by high-throughput, high specificity and high-sensitivity. Therefore, proteomics has become a major focus of recent medical research.
This study will examine the peritoneal tissue, serum and dialysate proteins of continuous ambulatory peritoneal dialysis (CAPD) patients with different types of peritoneal solute transport by differential proteomics techniques. Correlation analysis will be used for the relationship between clinical data and the differential proteins, as well as verification of the differential proteins in the peritoneal tissue, serum and dialysate of patients with UFF. This study will be performed to identify the molecular difference between different types of peritoneal solute transport and explore biomarker for early detection as well as early intervention of peritoneal ultrafiltration failure.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00728806
|Contact: Xueqing Yu, M.D.& Ph.D.||firstname.lastname@example.org|
|Contact: Haiping Mao, M.D.& Ph.D.||8620-87755766 ext email@example.com|
|The 1st Affiliated Hospital, Sun Yet-sen University||Recruiting|
|GuangZhou, Guangdong, China, 510080|
|Contact: Xueqing Yu, M.D. & Ph.D. 8620-87766335 firstname.lastname@example.org|
|Contact: Haiping Mao, M.D. & Ph.D. 8620-87755766 ext 8143 email@example.com|
|Principal Investigator: Xueqing Yu, M.D.& Ph.D.|
|Principal Investigator:||Xueqing Yu, M.D. & Ph.D.||1st Affiliated Hospital, Sun Yat-Sen University|