Intramuscular Lipid and Insulin Action:Ethnic Aspects (QuEST)
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Purpose
High levels of the hormone insulin are associated with risk for heart disease and diabetes, and may make it hard to lose weight. The types of food eaten may affect insulin levels. The purpose of this study is to determine if manipulation of dietary carbohydrate content improves insulin sensitivity (Si), augments weight loss, and promotes weight loss maintenance in healthy adults.
| Condition | Intervention |
|---|---|
|
Obesity |
Dietary Supplement: Low carbohydrate |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Subject) Primary Purpose: Basic Science |
| Official Title: | Intramuscular Lipid and Insulin Action:Ethnic Aspects |
- Insulin sensitivity [ Time Frame: IVGTT and minimal model ] [ Designated as safety issue: No ]
- Weight loss [ Time Frame: Weight loss over 8 weeks ] [ Designated as safety issue: No ]
| Enrollment: | 69 |
| Study Start Date: | April 2007 |
| Study Completion Date: | December 2009 |
| Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
-
Dietary Supplement: Low carbohydrate
Eligibility| Ages Eligible for Study: | 21 Years to 50 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Overweight, age 21-50 years,Women must be premenopausal, Normal glucose tolerance, weight stable for at least 6 months with a weight change no greater than 5 lbs.
Exclusion Criteria:
Exclusion criteria were type 1 or type 2 diabetes, polycystic ovarian disease, BMI <26.5 or weight >300 pounds, weight change >5 pounds in last 6 months, regular exercise >2 hours per week, pregnancy, currently breastfeeding, cholesterol medications, any disorders of glucose or lipid metabolism, use of medication that could affect body composition or glucose metabolism (including oral contraceptives and blood pressure medications), current use of tobacco, use of illegal drugs in last 6 months, history of hypoglycemic episodes, major food allergies or food dislikes, women with inconsistent or absence of monthly menstrual cycles, and a medical history that counter-indicated inclusion in the study.
Contacts and Locations| United States, Alabama | |
| University of Alabama at Birmingham | |
| Birmingham, Alabama, United States, 35294 | |
| Principal Investigator: | Barbara A Gower, PhD | Univ. Alabama Birmingham |
More Information
No publications provided by University of Alabama at Birmingham
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Barbara Gower, Professor, University of Alabama at Birmingham |
| ClinicalTrials.gov Identifier: | NCT00726908 History of Changes |
| Other Study ID Numbers: | F070322005, R01DK067538 |
| Study First Received: | July 29, 2008 |
| Last Updated: | June 14, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Alabama at Birmingham:
|
Obesity diet carbohydrate insulin |
Additional relevant MeSH terms:
|
Obesity Overnutrition Nutrition Disorders Overweight Body Weight |
Signs and Symptoms Insulin Hypoglycemic Agents Physiological Effects of Drugs Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 23, 2013